维甲酸固体脂质纳米粒的制备及兔体外透皮研究  

Preparation and Transdermal Permeation in Rabbits of Solid Lipid Nanoparticles Loaded with Retinoic Acid

作　　者：陆杨燕[1,2] 周华锋[1,2] 夏强[1] 马全红[1,2] 顾宁[1] 

机构地区：[1]东南大学分子与生物分子电子学国家重点实验室,江苏省生物材料与器件高技术重点实验室,东南大学生物科学与医学工程系,江苏南京210096 [2]东南大学化学化工系

出　　处：《中国医药工业杂志》2006年第1期17-19,共3页Chinese Journal of Pharmaceuticals

基　　金：江苏省自然科学基金创新人才项目(BK2002404);江苏省发展计划委员会资助项目(7607038009)

摘　　要：利用含维甲酸微乳60℃时的相图优化制备其固体脂质纳米粒(SLN)条件。结果表明,脂质材料甘油单硬脂酸酯与混合乳化剂[硬脂酸聚烃氧(40)酯-泊洛沙姆(7∶3)]的最佳配比为1∶6。按优化处方制备的SLN粒径随药物含量增加而略有增大,含量为182μg/ml的SLN25℃避光放置120d,平均粒径为(12.8±0.7)nm。兔离体皮肤试验表明,该制品8h累积透过量明显高于维甲酸乳膏。The preparation of solid lipid nanoparticles （SLN） of retinoic acid was optimized based on the phase diagram of drug-loading microemulsion at 60℃. Glyceryl monostearate was used as lipid carrier. The results showed that the optimized ratio of carrier and emulsifiers polyoxyethylene （40） stearate-Poloxamer F-68 （7 ： 3） was 1 ： 6 and the particle size of retinoic acid SLN was slightly increased with the increasing of drug loading. The mean diameter of the product with drug loading of 182μg/ml stored at 25 ℃ protected from light for 120d was （12.8 ± 0.7） nm. The accumulative amount of permeation for 8h through the excised rabbit skin was significantly greater than that of retinoic acid cream.

关 键 词：维甲酸 固体脂质纳米粒 相行为 透皮 

分 类 号：R944.9[医药卫生—药剂学]