补肾法对冠心病心绞痛患者NO、NOS、ET的影响  

Influences on NO, NOS, ET of the Therapy of Tonifying the Kidney in Treating Patients of Angina Pectoris

作　　者：杨焕斌[1] 林坚[1] 罗陆一[1] 

机构地区：[1]深圳市中医院,广东深圳518033

出　　处：《中国中医药信息杂志》2006年第1期18-20,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：广东省中医药管理局立项课题(400024)

摘　　要：目的观察补肾法对冠心病心绞痛患者一氧化氮(NO)、一氧化氮合酶(NOS)、内皮素(ET)的影响。方法用单硝酸异山梨酯作为对照,服药前后记录NO、NOS、ET、心绞痛症状、心电图ST-T改变、动态心电图缺血性ST-T改变的时间、血液流变学和血脂的情况。结果补肾中药治疗后,患者NO、NOS明显升高,ET明显下降;NO由(46.42±7.94)μmol/L改善为(70.16±12.94)μmol/L,NOS由(1.62±0.22)u/mL改善为(2.36±0.30)u/mL,ET由(64.46±15.12)pg/mL改善为(41.42±8.76)pg/mL;心绞痛总有效率为92%,心电图改善总有效率为68%,动态心电图缺血性ST-T改变的时间由(104.70±12.25)min改善为(24.26±3.41)min,与单硝酸异山梨酯治疗的对照组相比,有明显差异(P<0.05)。结论补肾法治疗冠心病心绞痛疗效明显,能明显升高NO、NOS,明显降低ET,且没有任何毒副作用。Objective To observe the influences on NO, NOS, ET of the Therapy of Tonifying the Kidney in patients with angina pectoris. Methods 50 patients with angina pectoris were treated by Chinese medicine of tonifying the kindey and the NO, NOS, ET, symptoms, ECG （ischemic ST-T changes）, holter ECG, blood viscosity and blood fat were recorded. Results Obvious rise of NO, NOS and drop of ET. The improving of NO（μmol/L） from 46.42±7.94 to 70.16±12.94, NOS（u/mL） from 1.62±0.22 to 2.36±0.30, ET（pg/mL） from 64.46±15.12 to 41.42±8.76, the total efficacy of Chinese medicine of tomifying the kidney to improving of angina pectoris amounted to 92%, to improving of ECG amounted to 68%, the improving time （minutes） of holter ECG from 104.70±12.25 to 24.26 ±3.41. The rise of NO, NOS, the drop of ET and the therapeutic efficacy of Chinese medicine of tonifying the kidney are better than isosorbidi mononitratis with significant difference （P 〈0.05）. Conclusion Chinese medicine of tonifying the kidney is useful to the treatment of angina pectoris, obvious rise of NO, NOS and obvious drop of ET without any side effect.

关 键 词：冠状动脉疾病 心绞痛 补肾法 一氧化氮 一氧化氮合酶 内皮素 

分 类 号：R259.414[医药卫生—中西医结合]