乳增平颗粒对乳腺小叶增生模型大鼠的影响  

Experimental Study of Ruzengping Granule on Hyperplasia of Mammary Glands in Model Rats

作　　者：阴景峰 于静华[1] 孙庆录 丁云录 张秀波[1] 陈声武[1] 

机构地区：[1]吉林天药科技有限公司,吉林长春130012

出　　处：《中国中医药信息杂志》2006年第1期24-25,共2页Chinese Journal of Information on Traditional Chinese Medicine

摘　　要：目的观察乳增平颗粒对乳腺增生病动物模型的治疗作用。方法采用苯甲酸雌二醇联合黄体酮肌注35d的方法,复制大鼠乳腺增生模型,用乳增平颗粒4.0、2.0、1.0g/kg3个剂量治疗30d,测定大鼠乳头直径,观察乳头大体形态变化及显微镜下乳腺组织变化,观察血流变学的影响;测定血清雌二醇(E2)含量。结果乳增平颗粒能明显减小大鼠增生乳头直径、减轻乳头形态学症状,减少乳腺小叶数、腺泡数和腺泡腔直径,改善血液流变性,显著降低血清E2含量。结论乳增平颗粒对雌激素引起的大鼠乳腺增生病有较好的疗效。Objective To observe the effect of Ruzengping granule on mammary gland of rat with mastoplasia. Methods After benzoate estradiol and progestogen had been injected into rats for 35 days, the mastoplasia model was made. The model rats were treated with Ruzengping granule for 30 days, to m^asure the mammary papilla diameter of the rats in all groups, to observe morphologic changes of mammary papilla and the changes of mammary gland under microscope, to determine the content of estradiol in blood serum and blood rheology by radio-immunity. Results Ruzengping granule could significantly inhibit the mammary papilla＇s diameter of the mastoplasia rats, lessen mammary papilla＇s symptoms in morphology, reduce the quantity of lobule of mammary gland, lobule-alveolus in mammary gland and the diameter of acinar lumina. Ruzengping granule could also significantly improve blood rheological nature and degrade content of estradiol in blood serum. Conclusion Ruzengping granule can healing efficaciously rat＇s mastoplasia induced by benzoate estradiol.

关 键 词：乳增平颗粒 乳腺增生病 雌激素 大鼠 

分 类 号：R269.558[医药卫生—中西医结合]