当归四逆加吴茱萸生姜汤和北细辛对小鼠肾脏组织细胞Ca^(2+)、Na^+-K^+-ATP酶的影响  

Experimental Studies on Effect of Danggui Sini plus Wuzhuyu Shengjiang Tang and Asarum Heterotropoides Fr.var. mandshuricum Kitag. on Ca^(2+) and Na^+-K^+-ATPase of the Small Mices' Renalis

作　　者：邓毅[1] 王昕[1] 张艳萍[2] 姚凝[1] 杨志军[1] 

机构地区：[1]甘肃中医学院,甘肃兰州730000 [2]甘肃中医学院附属医院,甘肃兰州730020

出　　处：《中国中医药信息杂志》2006年第1期35-36,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：甘肃省教育厅资助项目(034-04)

摘　　要：目的观察当归四逆加吴茱萸生姜汤(原方)、原方去木通和北细辛对肾脏毒性的作用。方法将小鼠随机分为4组,各组分别以生理盐水及药物灌胃,每日1次,连续给药21d。检测各组对小鼠肾脏组织细胞Ca2+含量、Na+-K+-ATP酶活性的影响。结果当归四逆加吴茱萸生姜汤等药物组对组织细胞Ca2+、Na+-K+-ATP酶等指标均有影响,具有统计学意义(P<0.05)。结论当归四逆加吴茱萸生姜汤(原方)组、原方去木通组、北细辛组对肾脏均产生毒性。Objective To approach the toxicity of Danggul Slnl plus wuznuyu Shengjiang ,ang and Asarum heterotropoides Fr.var. mandshuricum Kitag. Method To observe the Ca^2＋, Na^＋-K^＋-ATP ase from the mice renalis tissue in order to prove the medicine curative effect. Result The Danggui Sini plus Wuzhuyu Shengjiang Tang and Asarum heterotropoides Fr.var. mandshuricum Kitag. can obviously increase the Ca^2＋ and decrease the Na^＋-K^＋-ATP ase of the mice. Conclusion The Danggui Sini plus Wuzhuyu Shengjiang Tang and Asarum heterotropoides Fr.var. mandshuricum Kitag. has very obviously toxicity to mice by influence the Ca^2＋ and Na^＋-K^＋-ATP ase of the tissue homogenate.

关 键 词：中药复方 北细辛 肾损害 NA^+-K^+-ATP酶 当归四逆 吴茱萸生姜汤 小鼠 

分 类 号：R256.5[医药卫生—中医内科学]