双环醇治疗慢性乙型病毒性肝炎肝纤维化的临床研究  

Clinical study on bicyclol against liver fibrosis induced by chronic hepatitis B

作　　者：易建华[1] 李伟[1] 熊英[1] 曾令兰[1] 翁志宏[1] 蔡淑清[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院感染性疾病科,武汉430022

出　　处：《临床内科杂志》2006年第1期57-59,共3页Journal of Clinical Internal Medicine

摘　　要：目的研究双环醇对慢性乙型病毒性肝炎(乙肝)肝纤维化的治疗作用。方法以双环醇治疗慢性乙肝患者20例,疗程6个月。分别于治疗前后检测患者血清丙氨酸氨基转移酶(ALT)、γ谷氨酰转肽酶(GGT)及血清纤维化指标层粘连蛋白(LN)、Ⅳ型胶原(CⅣ)、Ⅲ型前胶原肽(PⅢP)和透明质酸(HA)水平。同时经皮肝活检观察治疗前后肝脏组织病理学变化。结果双环醇可以显著降低慢性乙肝患者血清ALT和GGT水平,复常率分别达95%和70%,同时可以明显降低慢性乙肝患者血清LN、CⅣ和PⅢP水平,尤其PⅢP和CⅣ水平与肝组织纤维化程度呈明显正相关(相关系数分别为0.653和0.530,P<0.01)。结论双环醇可以减轻慢性乙肝患者肝脏炎症反应,保护肝细胞和抑制肝纤维化。Objective To investigate the therapeutic effect of bicyclol on liver fibrosis induced by chronic hepatitis B. Methods A total of 20 patients with chronic hepatitis B were enrolled for treatment with bicyclol for 6 months. The serum ALT and GGT and serum fibrosis markers including laminin（ LN）, Ⅳ collagen （ C-Ⅳ ）, aminoterminal propeptide of type Ⅲ procollagen （ PⅢP） and hyaluronic acid （HA） were determined respectively before and after the treatment. The change of hlstopathology by liver biopsy was observed simultaneously. Results After the treatment with bicyclol, the serum levels of ALT, GGT and LN, C-Ⅳ, PⅣP in the patients with chronic hepatitis B significantly decreased. The serum levels of C- Ⅳ and PⅢ P were correlated positively with the degree of liver fibrosis （ r = 0.653 and r = 0.530 respectively, P 〈 0.01 ）. Conclusion Bicyclol can effectively treat liver fibrosis associated with chronic hepatitis B by protecting hepatocyte from damage and suppressing fibrosis aecumulation.

关 键 词：双环醇 肝纤维化 慢性乙肝 肝活检 

分 类 号：R512.62[医药卫生—内科学]