高通量血液透析对血清钙、磷和甲状旁腺素的影响  

Effects of high flux hemodialysis on serum calcium, phosphorus and parathyroid hormone

作　　者：范文奎[1] 杨红[1] 陈光贤[1] 周少雄[1] 梁艳影[1] 高爱华[1] 

机构地区：[1]广东省佛山市第二人民医院血液净化中心,528000

出　　处：《实用医学杂志》2006年第1期24-26,共3页The Journal of Practical Medicine

基　　金：广东省卫生厅立项课题(编号:A2002706)

摘　　要：目的:探讨高通量血液透析对血清钙、磷和甲状旁腺素(PTH)的影响。方法:采用双盲随机对照,A组应用高通量透析,B组应用普通透析,分时点检测病人空腹透析前血清总钙、磷和全段PTH的水平。结果:A组病人血清钙各时点均数在正常范围,相互比较无显著变化(P>0.05);血清磷和血清全段PTH在3个月时显著降低并维持犤血磷(1.98±0.08)mmol/L,血清全段PTH(256.16±101.22)pg/L犦,P<0.05。B组病人血清钙在正常范围,血清磷和血清全段PTH水平较高,各时点均数比较,P>0.05。A组血清磷和PTH在3个月时明显低于B组(P<0.05),之后维持;血清钙两组无差异。结论:高通量透析可增加血磷的清除量,有效降低维持性血液透析患者的血磷和PTH。Objective To explore the effects of high flux hemodialysis on serum calcium（Ca）, phosphorus（P） and parathyroid hormone （PTH）. Methods Forty-one patients with chronic kidney diseases were randomly divided into two groups. Group A used high flux hemodialysis; group B used low flux maintenance hemodialysis. Before eating breakfast and hemodialysis, the serum Ca and P and PTH of the patients were examined on the different times. Results Serum Ca of group A patients was in the normal degree on the different times , not significantly changing （P 〉 0.05） ; Serum P and PTH significantly reduced on the 3 month time and maintain later [P： （1.98 ±0.08） mmol/L,PTH： （256. 16±101.22） pg/L] , P 〈 0.05. Serum Ca of group B patients was in the normal degree , serum P and PIH were higher than those of the normal degree , they were not significantly changing on the different times （P 〉 0.05） . To compared group A with group B , serum P and PTH of group A were significantly lower than those of group B on the 3 month time, P 〈 0.05; serum Ca was not significantly different （P 〉 0. 05） . Conclusion When the patients were treated with high flux hemodialysis, serum P can be more cleaned, serum P and PTH can significantly reduce in the maintenance hemodialysis patients.

关 键 词：肾透析 高通量透析 血磷 血钙 甲状旁腺素 

分 类 号：R459.5[医药卫生—治疗学] R692.5[医药卫生—临床医学]