阿克拉霉素A固体脂质纳米粒冻干针剂在家兔体内药动学  

Study on the pharmacokinetics of lyophilized injection of aclacinomycin A solid lipid nanoparticles in rabbit

作　　者：何林[1] 李素华[2] 黄亮[2] 孙世明[1] 蒋学华[2] 

机构地区：[1]四川省人民医院,四川成都610072 [2]四川大学华西药学院,四川成都610041

出　　处：《中国医院药学杂志》2006年第1期3-5,共3页Chinese Journal of Hospital Pharmacy

基　　金：四川省科技厅重点科技项目(编号:01SY051-41)

摘　　要：目的:研究阿克拉霉素A固体脂质纳米粒(ACM-SLN)冻干针剂在家兔体内的药物动力学。方法:用RP-HPLC法测定家兔耳缘静注ACM-SLN冻干针剂和阿克拉霉素A(ACM-A)注射剂后不同时间血浆中ACM-A的浓度,绘制药-时曲线,计算药物动力学参数。结果:ACM-SLN冻干针剂和ACM-A注射剂的体内过程均符合二室模型,ACM-SLN冻干针剂的t1/2β与MRT显著延长,AUC增高,CL降低。结论:ACM-SLN冻干针剂有利于增加药物与肝脏肿瘤组织的接触时间,从而提高ACM-A的抗肝癌作用。OBJECTIVE To study the pharmacokinetics of lyophilized injection of aclacinomycin A solid lipid nanoparticles （ACM-SLN）. METHODS ACM-A was determined by RP-HPLC after iv. administration to rabbits. The mean plasma concentration-time data were obtained and pharmacokinetic parameters were calculated using 3p87. RESMLTS The plasma concentrationtime courses of ACM-SLN lyophilized injection and ACM-A injection were both conformed to two-compartment model. The parameters of t1/2β ,MRT of ACM-SLN lyophilized injection were markedly longer than those of ACM-A injection, AUC was significantly increased and CL was significantly reduced. CONCLUSION The residence time of ACM-SLN in blood can be markedly prolonged resulting in the increasing of ACM-A concetration in liver so as to enhance its antihepatoma effect.

关 键 词：阿克拉霉素A 固体脂质纳米粒 药物动力学 针剂 肝脏肿瘤 抗肝癌作用 

分 类 号：R969[医药卫生—药理学]