虫草洋参胶囊抗疲劳与免疫作用及急性毒性实验  

Anti-fatique and immune function of compound Chongcaoyangshen capsule

作　　者：杨成雄[1] 夏继伟 杨希雄[1] 裴光明 王锦军[1] 芦金清[4] 

机构地区：[1]荆门职业技术学院,湖北荆门448000 [2]荆门市第二人民医院,湖北荆门448000 [3]湖北省京山县中医院,448000 [4]湖北中医学院,湖北武汉430070

出　　处：《中国医院药学杂志》2006年第1期10-11,共2页Chinese Journal of Hospital Pharmacy

基　　金：湖北省重点科技发展指导性项目(编号:20001B43)

摘　　要：目的:虫草洋参胶囊的抗疲劳、免疫作用、急性毒性试验。方法:以小白鼠游泳时间和常压密闭容器中死亡时间为指标研究抗疲劳及耐缺氧的药理作用;对小鼠碳粒廓清影响的免疫作用;急性毒性试验测定虫草洋参胶囊的最大耐受量。结果:虫草洋参胶囊大、小剂量组游泳时间分别为(5.0±1.3)m in和(4.7±1.5)m in,生理盐水组为(3.7±1.0)m in,差异有极显著性(P(0.01);给药组存活时间(50.7±11.2)m in,生理盐水组为(41.2±15.2)m in,差异有显著性(P(0.05);对小鼠非特异免疫的功能———单核巨噬细胞吞噬功能具有明显促进作用;虫草洋参胶囊在剂量为15g.kg-1.d-1时,对小鼠不引起毒性反应。结论:此复方制剂有抗疲劳和耐缺氧的作用,对免疫有明显的促进作用,且毒性较小。OBJECTIVE To study immue and anti-fatigue effect and acute toxicity of Chongcaoyangshen capsules. METHODS Mices swimming time and enduring time under normal pressure in a hermetical container was calculated. Phagocytosis of mononuclear macrophage was determined with carbon particle clearance test. The max dose was measured by the acute toxicity tests. RESULTS In certain doses（ 15 g· kg^-1·d-1）, the chongcaoyangshen capsules were not toxic to mice and significantly increased phagocytic function and performed a remarkable function on fatique in anosic condition by tests on mice, CONCLUSION These results suggest that Chongcaoyangshen capsules have little toxicity and have anti-fatlque effects and significantly prcmote immunereguulation function and endurance in anoxic condition.

关 键 词：虫草洋参胶囊 抗疲劳 耐缺氧 免疫作用 最大耐受量 

分 类 号：R965[医药卫生—药理学]