经皮冠状动脉介入治疗不稳定型心绞痛和非ST段抬高心肌梗死的临床研究  

Percutaneous coronary intervention for treatment of unstable angina or non-ST-segment elevation myocardial infarction

作　　者：黄树温[1] 李克清[1] 王磊[1] 牟瑞起[1] 王荣彬[1] 张雁[1] 

机构地区：[1]德州市人民医院心内科,德州市253014

出　　处：《滨州医学院学报》2005年第6期404-407,共4页Journal of Binzhou Medical University

摘　　要：目的比较不稳定型心绞痛和非ST段抬高心肌梗死患者应用经皮冠状动脉介入治疗和药物治疗的疗效.方法选择我院心内科病房住院的不稳定型心绞痛和非ST段抬高心肌梗死患者共536例,分为药物保守治疗组和经皮冠状动脉介入治疗组.介入治疗组在药物治疗基础上于入院1～10 d行冠状动脉造影,据结果施行介入治疗术.随访患者1～24个月的心绞痛复发率、再次入院率和再次介入治疗率或血管搭桥术(次要终点),以及心源性死亡和(或)急性心肌梗死发生率(主要终点).结果 260例病人施行介入治疗,276例病人接受药物治疗.在1～24(1,6,12,24)个月随访中,介入治疗组的心源性死亡和(或)急性心肌梗死发生率明显低于药物治疗组(分别为1.2%:4.7%,1.2%:5.8%,1.9%:5.4%,1.5%:6.9%,P均<0.01);心绞痛复发率介入治疗组明显低于药物治疗组(6.1%:20.3%,10%:35.5%,11.9%:40.6%,13.5%:44.6%,P均<0.001);再入院率介入治疗组明显低于药物治疗组(5%:18.5%,8.1%:32.6%,10.4%:37.3%,10%:42.1%,P均<0.001);再次接受介入治疗或血管搭桥术的病人在介入治疗组亦明显低于药物治疗组(1.5%:5.8%,2.3%:8.0%,3.1%:6.5%,3.5%:8.3%,P均<0.01).结论经皮冠状动脉介入治疗能显著改善不稳定型心绞痛和非ST段抬高心肌梗死患者的预后,优于传统的药物治疗,可作为大多数患者的首选治疗方法.Objective To compare the efficacy of percutaneous coronary intervention（PCI） with that of drug therapy in patients with unstable angina or non-ST-segment elevation myocardial infarction. Methods 536 patients with unstable angina or non-ST-Segment elevation myocardial infarction were divided into two groups （ conservative vs PCI） according to management strategy. In PCI group, coronary angiography and PCI were performed 1 - 10 days after admission. Patients were followed up for 1-24 months. Cardiac death and acute myocardial infarction were the primary endpoint. Recurrence angina,readmisson and revascularization were the second- ary endpoint. Results There were 260 patients in PCI group and 276 patients in conservative group. During follow-up（ 1,6,12,24 months） ,there was a decrease in the primary endpoint in the PCI group compared with that in conservative group （ 1.2% vs 4.7% , 1.2% vs 5.8%, 1.9% vs 5.4% , 1.5 % vs 6. 9% , P 〈 0.01 ）. The rates of recurrent angina（ 6.1% vs 20. 3 % , 1% vs 35.5 % , 11.9% vs 40. 6% , 13.5% vs 44. 6% ,P 〈 0. 001 ） , readmission （ 5% vsl8.5%, 8. 1% vs 32. 6% , 10. 4% vs 37. 3% , 1% vs 42. 1% , P 〈 0. 001 ） and revaseularization（1.5 % vs 5.8% ,2. 3 % vs 8.0% , 3. 1% vs 6. 5 % , 3.5 % vs 8.3 % , P 〈 0. 01 ） were significantly lower in the PCI group compared with those in the conservative group. Conclusion Our data indicate that the invasive approach may be the preferred strategy in patients with unstable angina or non-ST-segment elevation myocardial infarction.

关 键 词：经皮冠状动脉血管成形术 心绞痛 非ST段 心肌梗死 

分 类 号：R541.4[医药卫生—心血管疾病]