左室功能减退窦性心律患者心房肌短暂外向钾电流mRNA表达的变化  

Alterations of mRNA Expression of Transient Outward K Current in Atria of Patients With Sinus Rhythm and Decreased Left Ventricular Function

作　　者：高梅[1] 侯应龙[1] 周聊生[1] 时昌文[2] 刘纪改[1] 王清[1] 王奖荣[1] 孙颖颖[1] 

机构地区：[1]山东大学临床医学院山东省千佛山医院心内科,山东济南250014 [2]山东大学临床医学院山东省千佛山医院普外中心实验室

出　　处：《中国心脏起搏与心电生理杂志》2005年第6期455-457,共3页Chinese Journal of Cardiac Pacing and Electrophysiology

基　　金：山东省卫生厅资助课题(批准号:HC119)

摘　　要：探讨心力衰竭患者易患心房颤动(AF)的可能发生机制之一。采集左室功能减退组患者(n=18例)和左室功能正常组患者(n=18例)的右心耳组织,应用逆转录聚合酶链反应技术(RTPCR)以3磷酸甘油醛脱氧酶(GAPDH)为内参照,测定心房肌KV4.3α的mRNA表达水平,反应心房肌短暂外向钾电流(Ito1)的变化。结果:与左室功能正常组相比,左室功能减退组心房肌KV4.3α的mRNA表达减低46.20%(0.83±0.07vs0.45±0.09,P<0.01)。结论:左室功能减退患者心房肌KV4.3αmRNA表达降低。To investigate the potential mecbanisms of atrial fibrillation in heart failure, right atrial appendages were obtained from 18 patients with decreased left ventricular function and 18 matched controls with normal left ventricular function. All patients were in sinus rhythm. The mRNA expression of I,o1 （KV4.3α） was measured by reverse transcripfion-polymerase chain reaction and normalized to the mRNA level of glyceraldehydes-3-phosphate dehydrogenase. Results： Compared to the control, the mRNA level of Itol （KV4.3α） in patients with decreased left ventricular function reduced by 46.20% （0.83 ±0.07 vs 0.45±0.09 ,P 〈0.01 ）. Conclusion： The mRNA level of Itol （KV4.3α） is down-regulated in patients with decreased left ventricular function.

关 键 词：心血管病学 心力衰竭 心房颤动 短暂外向钾电流 基因表达 

分 类 号：R541.61[医药卫生—心血管疾病] R541.75[医药卫生—内科学]