新生儿窒息血自由基IL-6变化与临床意义  

The Clinical Significance of Free Radical and IL-6 in Serum in Asphyxia of Newborns

作　　者：王立金[1] 王慧[2] 

机构地区：[1]安徽理工大学医学院,安徽淮南232001 [2]淮南新华医疗集团新华医院儿科,安徽淮南232052

出　　处：《安徽理工大学学报（自然科学版）》2005年第4期94-96,共3页Journal of Anhui University of Science and Technology:Natural Science

摘　　要：研究新生儿窒息对血清中NO、SOD、MDA和IL-6的水平变化与临床意义。选用新生儿窒息患儿54例(轻度窒息34例,重度窒息20例),分别于生后第1天和第7天采取静脉血检测血清NO、SOD、MDA和IL-6水平。12例无窒息史新生儿作为对照组。结果表明:新生儿窒息组血清NO、MDA和IL-6水平明显高于对照组,血清SOD活性明显低于对照组,均有统计学意义。两组比较:NO含量(P<0．05)、SOD(P<0．01)、MDA(P<0．05)、IL-6(P<0．01); 且新生儿窒息组在住院治疗第7天时,血清NO、MDA和IL-6水平比住院第1天时明显降低,血清SOD活性明显回升,均P<0．01。而轻度与重度窒息组之间血清NO、SOD、MDA和 IL-6水平比较亦存在着差异,具有统计学意义(P<0．01)。为此,新生儿窒息的发病机制与自由基和IL-6有关,检测血清NO、SOD、MDA和IL-6水平可作为判定新生儿窒息病情程度及预后的重要指标。Objective. To evaluate the change of serous NO, SOD. MDA and IL-6 levels in asphyxial newborns. Methods. Levels of NO.SOD.MDA and IL-6 in serum were measured in 54 newborns with asphyxia （34 cases with mild and 20 cases with severe status） at the first day and the seventh day after birth and in 12 cases of normal control groups. Results. Serum levels of NO. MDA and IL- 6 in asphyxial group were obviously higher than those in the normal control group （p〈0. 01）. but obviously decreased at the seventh day than those at the first day（p〈0. 01）. SOD activity of serum in asphyxial group were obviously lower than that in the normal control group （p〈0. 01） ,but obviously increased at the seventh day than that at the first day （p〈0. 01）. There were statistically significant differences between mild and severe asphyxial group （p〈0. 01）. Conclusion. The changes of free radical level and IL-6 level were correlated with asphyxial pathogenesis newborns. NO.SOD.MDA and IL-6 can play an important role in the pathologic process of asphyxia of newborns.

关 键 词：婴儿 新生 窒息 一氧化氮 超氧化物歧化酶 丙二醛 白介素-6 

分 类 号：R722.12[医药卫生—儿科]