叶酸、维生素E对Hcy血症小鼠血脂及抗氧化酶活性影响  

Effects of Folic acid and Vitamin E on plasma Lipids and activity of SOD、GSH-Px in Hcy mice

作　　者：李淑莲[1] 聂晓兰[1] 张永雪 

机构地区：[1]河南大学医学院病理生理教研室 [2]开封95936部队医院

出　　处：《河南大学学报（医学版）》2005年第4期14-16,共3页Journal of Henan University:Medical Science

摘　　要：目的:观察叶酸、V itE对高同型半胱氨酸血症小鼠血脂及心、肝抗氧化酶活力的影响。方法:复制高同型半胱氨酸(homocyste ine Hcy)血症小鼠模型,腹腔注射叶酸、V itE、叶酸+V itE,测定血浆TC、TG、HDL-C、LDL-C及心、肝SOD、GSH-PX活力。结果:Hcy增高小鼠血脂水平,TC、TG、LDL-C与对照组比较均升高;降低心、肝SOD、GSH-Px活力。叶酸、V itE可降低Hcy所致的血脂水平升高,提高Hcy所致的抗氧化酶活力下降,叶酸与V itE同时应用效果更佳。结论:叶酸+V itE显著降低高Hcy血症小鼠血脂水平,提高高Hcy血症小鼠抗氧化酶活力。Objective： To Study the effect of Folic acid （FA） and Vitamin E （VitE） on plasma Lipids and activity of SOD, GSH - Px in Hcy mice, and to find out the measurement to control cardiovascular disease. Methods： Intraperitoneal injection of homocysteine into mice induced hyperhomocysteinemia. The levels of plasma lipids and activity of SOD, GSH - Px were observed after intrapertoneal injection of Folic acid and Vitamin E into mice. Results： The contents of TC, TG and LDL - C in Hcy group increased by 27% （ P 〈 0.01） , 43% （ P 〈 0.01） , and 46% （ P 〈 0.01）, compared with that of the control group , activity of SOD, GSH - Px in heart decreased by 27% （ P 〈 0.01） , 23% （ P 〈 0.01）, levels of TC, TGandLDL-C deceased by 19%（P〈0.01）,19%（P〈0.05）,33%（P〈0.05）. Folic acid and Vitamin E can reduce the rising of plasma lipids, increase the falling of antioxidation induced by hyperhomocysteinemia, in FA ＋ VitE ＋ Hcy group. Activity of SOD, GSH - Px in heart increased by 28% （ P 〈 0.01）, 22% （ P 〈 0.01）, Compared with Hcy - group. Conclusion： FA ＋ vitE obviously decreases the levels of plasma lipids in high Hcy - mice, increase the activity of antioxidation in heart and liver of high Hcy - mice.

关 键 词：叶酸 维生素E 血脂 高同型半胱氨酸血症 

分 类 号：R965[医药卫生—药理学]