辅酶Q_(10)对大鼠阿霉素心脏毒性的保护作用  

The Protective Effect of Coenzyme Q_(10) on Adriamycin-Induced Cardiotoxicity in Rats

作　　者：吴晓晖[1] 盛红专[1] 黄宗勤[1] 邹毓斌[1] 

机构地区：[1]南通大学附属医院心内科,江苏南通226001

出　　处：《南通大学学报（医学版）》2005年第6期405-406,409,共3页Journal of Nantong University(Medical sciences)

摘　　要：目的:研究辅酶Q10(CoQ10)对大鼠阿霉素心脏毒性的保护作用,并探讨可能的机理。方法:采用离体心脏灌流方法,实验分3组:对照组、阿霉素组、CoQ10组,监测大鼠心肌收缩幅度、冠脉流量、心电图的变化,并测定冠脉流出液肌酸磷酸激酶(CPK)活力和大鼠心肌丙二醛含量、超氧化物歧化酶、谷胱甘肽过氧化物酶(GSH-Px)活力以及电镜下超微结构的改变。结果:CoQ10可改善阿霉素引起的大鼠心肌收缩幅度、冠脉流量下降,减少心律失常的发生,降低冠脉流出液CPK活力;CoQ10组心肌丙二醛含量明显低于阿霉素组、SOD和GSH-Px活力高于阿霉素组,电镜下超微结构变化亦优于阿霉素组。结论:CoQ10对阿霉素引起的心脏毒性具有保护作用,其机理可能与CoQ10拮抗阿霉素的氧自由基损伤有关。Objective ：To investigate the effect of coenzyme Q10 on adriamycin - induced cardiotoxicity in rats. Methods ：The study was performed by de vivo perfused methods, and rats were randomly divided into three groups：a control one,an adriamycin one and an adriamycin ＋ coenzyme Q10 one. The level of contractility, coronary fluence and electrocardiogram, the content of malondialdehyde,SOD and GSH - Px in the myocardium were monitored. In addition,the changes in myocardial ultrastructure were assessed by means of transmission electron microscope. Results：Myocardial contractibility and coronary fluence were improved and arrhythmia was reduced in the adriamycin ＋ coenzyme Q10 group. Besides the content of malondialdehyde was lower, the activities of SOD and GSH - Px were higher, and ultrastructures were better in the adriamycin ＋ coenzyme Q10 group than in the adriamycin group. Conclusion ：Coenzyme Q10 has a protective effect on adriamycin -induced cardiotoxicity.

关 键 词：辅酶Q10 阿霉素 心脏毒性 丙二醛 超氧化物歧化酶 大鼠 

分 类 号：R978.7[医药卫生—药品]