重组乙型肝炎疫苗(酵母)免疫后10年的抗体持久性及免疫记忆观察  

Observation on the Immune Persistence of Recombinant Yeast-derived Hepatitis B Vaccine(YDV) After 10 Years Vaccination

作　　者：安建会[1] 邢秀生[2] 闫以让 何晓红[4] 光明[1] 李国英[1] 李太生[1] 常少英[1] 范富云[1] 翟如芳[1] 

机构地区：[1]山西省疾病预防控制中心,太原030012 [2]阳泉市疾病预防控制中心,山西阳泉045000 [3]晋中市疾病预防控制中心,山西晋中030600 [4]大同市疾病预防控制中心,山西大同037004

出　　处：《中国计划免疫》2005年第6期470-472,共3页Chinese Journal of Vaccines and Immunization

摘　　要：目的观察重组乙型肝炎(乙肝)疫苗(酵母)(YDV)免疫后10年的抗体持久性及免疫记忆。方法追踪观察按照免疫程序全程免疫后10年儿童的乙肝病毒表面抗体(抗-HBs)持久性;分别对免疫后5年和10年抗-HBs阴转的儿童,加强免疫YDV 1剂,观察其免疫记忆反应。结果抗-HBs阳性率、有效阳性率、几何平均滴度逐年下降,分别由免疫后1年的92.08%、84.16%、29.21mIU/ml降至10年后的65.17%、40.45%、5.38mIU/ml;年均递减率分别为3.76%、7.82%、17.14%。抗-HBs阳性率下降速率较慢,而有效阳性率则较快,并随免疫时间的延长,各项指标的年均递减率逐年降低,推测免疫的低阳性率水平可能维持较长时间。结论YDV免疫后存在较好的免疫记忆,免疫后10年无需加强免疫。Objective To observe the immune persistence of Recombinant Yeast-derived Hepatitis B Vaccine （YDV） and its immune memory. Methods Persistence of anti-HBs in children who had been vaccinated with full course of YDV 10 years ago was observed. Immune memory in the children who had been turned to negative after 5 and 10 years vaccinating and boost 1 dose YDV has been observed. Results Positive rate of anti-HBs was decreased from 92.08 % to 65.17 %, effective positive rate was decreased from 84.16% to 40.45 % and the mean geometric titres（GMTs） was decreased from 29.21 mIu/mL to 5.38 mIU/mL compared with 1 year later basic vaccination. Decreased rate was 3.76 % ,7.82 %, and 17.14 % respectively averagely. The results showed that with immune time extending, each target decreased year by year,which indicating that the low positive rate might keep longer time. Conclusion There is good immune memory after 10 years YDV vaccination, it is unnecessary to consider the boosting.

关 键 词：重组乙型肝炎疫苗(酵母) 抗体持久性 免疫记忆 

分 类 号：R186[医药卫生—流行病学] R512.62[医药卫生—公共卫生与预防医学]