27例丙基硫氧嘧啶致药物不良反应的分析  

Analysis of Drug Adverse Reactions Induced by Propacil in 27 Cases

作　　者：梁雁[1] 吴春颖[1] 张海燕[1] 鲁云兰[1] 崔一民[1] 

机构地区：[1]北京大学第一医院,北京市100034

出　　处：《中国医院用药评价与分析》2005年第6期375-377,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:对丙基硫氧嘧啶所致药物不良反应进行分析。方法:采用回顾性分析的方法,对我院1998年1月至2005年3月临床各科室报告的丙基硫氧嘧啶所致27例药物不良反应病例进行统计和分析。结果:27例药物不良反应中居首位为肝损害占34.38%,其次为小血管炎占28.12%,第3位为药疹占25.00%。ADR的潜伏期中位数为23天(最短2天,最长2 400天)。其严重程度:中度占47.83%,重度占52.17%。经及时停药并对症治疗,均治愈或好转。结论:丙基硫氧嘧啶所致27例药物不良反应均为中、重度,且服药至出现药物不良反应的潜伏期差异较大。因此定期检查肝、肾功能,血常规,及时调整治疗方案,加强对患者的教育,是预后良好的关键。OBJECTIVE： To analyze drug adverse reactions induced by propacil. METHODS： By taking retrospective analysis, 27 cases with drug adverse reactions induced by propacil, reported by clinical departments during the period Jan 1998 to March 2005, were counted up and analyzed. RESULTS： Of 27 cases with drug adverse reactions, hepatic lesion ranked first（34.38% ）,polyangitis was the second （28.12%）and drug rash was the third （25.00%）. Median of latency of ADR was 23 days （the shortest latency was 2 days, the longest was 2 400 days）. Severity degree of ADR： moderate was 47.83%, severe was 52.17%. After promptly stopping taking the drug and carrying out symptomatic treatment, drug adverse reactions were cured or improved. CONCLUSION： 27 cases with ADR induced by propacil are all moderate and severe. The latency from taking the drug till occurring ADR has great difference. Therefor, periodic inspection of the liver, the kidney and blood routine examination, adjusting treatment plan timely and strengthening instruction to the patients are the key point in prognosis.

关 键 词：丙基硫氧嘧啶 不良反应 分析 

分 类 号：R977.14[医药卫生—药品]