拉克替醇对慢性病毒性肝炎患者肠道菌群及内毒素血症的影响  

Effects of Lactitoi on intestinal flora and plasma endotoxin in patients with chronic viral hepatitis

作　　者：李兰娟[1] 陈春雷[1] 吴仲文[1] 陈湖光[1] 傅素珍[1] 盛吉芳[1] 

机构地区：[1]浙江大学医学院附属第一医院传染科,卫生部传染病重点实验室,杭州310003

出　　处：《中华传染病杂志》2005年第6期395-397,共3页Chinese Journal of Infectious Diseases

基　　金：国家"973"计划资助项目(2003CB515506)

摘　　要：目的观察拉克替醇对慢性病毒性肝炎患者肠道菌群及血内毒素水平的影响。方法60例慢性病毒性肝炎伴血内毒素升高的患者随机分为两组.对照组30例采用常规保肝降酶治疗.治疗组30例在常规治疗的基础上加用拉克替醇.观察两组患者治疗前及治疗3周后肠道菌群、血内毒素水平的变化。结果治疗组患者肠道内乳杆菌和双歧杆菌数量明显增加(P<0.01).产气荚膜梭菌显著降低(P<0.01).血内毒素水平显著降低(P<0.01)。结论拉克替醇能通过调节慢性病毒性肝炎患者肠道菌群,更有效降低血内毒素水平。Objective To investigate the effects of lactitol on intestinal flora and the levels of plasma endotoxin in the patients with chronic viral hepatitis. Methods Sixty patients with chronic viral hepatitis and gut-derived endotoxemia were randomly divided into two groups： lactitol group （n= 30） and control group （n= 30）. Patients in the control group received standard treatment for 3 weeks, while patients in the lactitol group received lactitol orally in addition to the standard treatment. Fecal flora and plasma endotoxin were measured before and after the treatment. Results In the lactitol group, the numbers of Bifidobacterium and Lactobacillus per gram of wet feces were significantly increased （P〈0.01） and Clostridium. perfringens count was decreased markedly （P〈0.01）. The levels of plasma endotoxin decreased after the treatment from 72.89 ng/L to 33.33 ng/L in the lactitol group and from 66.00 ng/L to 51.07 ng/L in the control group, but the plasma endotoxin levels in the lactitol group decreased far more than in the control group （P〈0.01）. Conclusions Lactitol can decrease the levels of plasma endotoxin more effectively than standard treatment in the patients with chronic viral hepatitis through improving intestinal microflora.

关 键 词：拉克替醇 肝炎 病毒性 人 肠道菌群 内毒素类 

分 类 号：R512.6[医药卫生—内科学]