茶碱血药浓度监测临床价值分析  

Analysis of clinical utilization of plasma theophylline concentration monitoring

作　　者：汪得喜[1] 袁建章[1] 邓哲彤[1] 伍惠红[1] 潘海燕[1] 

机构地区：[1]广州市红十字会医院/暨南大学第四附属医院呼吸内科,广东广州510220

出　　处：《广东药学院学报》2005年第6期706-707,共2页Academic Journal of Guangdong College of Pharmacy

摘　　要：目的了解茶碱血药浓度监测的临床使用价值.方法分析我院资料齐全的909例茶碱血药浓度(质量浓度)监测结果及相应临床膊资料.结果①除服茶碱自杀的1例病人外,其余908例病人中,首次检测茶碱血药浓度在5～20μg/mL范围内668例,超过20μg/mL者76例,低于5μg/mL者164例.②血药浓度超过20μg/mL者可表现出不同程度的消化、循环、神经系统表现,甚至因此死亡,但也可无临床表现.停药后血药浓度降低速度存在很大差异.③在口服茶碱制剂基础上静脉注射茶碱易诱发茶碱中毒.结论监测茶碱血药浓度有助于保证茶碱合理使用、及时诊断和处理茶碱中毒.Objective Evaluate clinical utilization of plasma theophylline concentration monitoring. Methods Plasma theophylline concentration monitoring materials of 909 patients and the relevant clinical manifestations were analyzed. Results ① Plasma theophylline concentrations were in the range of 5 - 20 μg/mL in 668 patients of 908 patients （ except one patient who committed suicide with theophylline）, surpassing 20 μmL in 76 patients, and lower than 5 μg/mL in 164 patients. ② Clinical manifestations in digestive, circulatory, and nervous systems and even death can be observed in patients with plasma theophylline concentration higher than 5 -20 μg/mL, or no clinical manifestation can be observed. The decreasing speed of plasma theophylline concentration after theophylline withdrawal is diversified significantly. ③Intravenous dripping of theophylline in addition to oral administration of theophylline tend to cause theophylline intoxication. Conclusion Plasma theophylline concentration monitoring can contribute to proper clinical utilization of theophylline, and diagnosis and treatment of theophylline intoxication.

关 键 词：茶碱 药物监测 血药浓度 

分 类 号：R96[医药卫生—药理学]