治疗围绝经期综合征中药小复方的筛选步骤与方法  

Steps and Methods in Choosing TCM small compound Prescriptions for Treatment of climacteric Syndromes in Perimenopause

作　　者：李东安[1] 梁茂新[1] 张慧颖[1] 张艳玲[1] 马杰[1] 李中平[1] 尤献民[1] 王树实[1] 

机构地区：[1]辽宁省中医药研究院,沈阳110034

出　　处：《世界科学技术-中医药现代化》2005年第6期31-36,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家中医药管理局资助课题(0203ZP20);中药小复方精选系统操作技术平台研究

摘　　要：目的:本文以治疗围绝经期综合征中药小复方为例, 进行Ⅱ期临床前中药小复方最佳配伍及最佳剂量配比的比较研究,借以建立中药小复方精选的技术平台。方法:运用拆方研究方法,以比较特异的药效学指标为评价指标,对3种制备工艺进行最佳制备工艺的筛选,以均匀设计法进行处方最佳配伍和最佳剂量配比的比较研究。结果:3种工艺中以根据药物理化性质选择的现代药学提取法为最好,以均匀设计法得出了处方最佳配伍及最佳剂量配比的实验值和理论值。结论:本研究方法在理论和实践中具有实际可行性。Objective Taking for example TCM small compound prescriptions for the treatment of climacteric syndromes in perimenopause the comparative study on the optimal compatibility and dose rate of TCM small compound prescriptions in the second preclinic phase is conducted to set up a platform for the choice of TCM small conpound prescriptions . Method To select the best preparative technology from among three such ones by the method of disassembling prescriptions and setting an exceptional experiment on pharmacodymamics as the index of its assessment and carry out comparative study of the optimal compatibility and dose rate of TCM prescriptions by the method of uniform design. Result Among the said three technologies the best one is the extraction method of modern pharmacy chosen in accordance of the physical and chemical properties of medicines involved, and the experimental and theoretical value of the optimal compatibility and dose rate of TCM prescriptions is achieved by the method of uniform design. Conclusion This study methodology is practically feasible in both theory and practice.

关 键 词：中药小复方 筛选方法 围绝经期综合征 

分 类 号：R711.75[医药卫生—妇产科学] R283.6[医药卫生—临床医学]