葛根组分库的构建  

Construction of component library of kudzu root

作　　者：张岩[1] 徐青[1] 薛兴亚[1] 章飞芳[1] 梁鑫淼[1] 

机构地区：[1]中国科学院大连化学物理研究所,大连116023

出　　处：《世界科学技术-中医药现代化》2005年第6期62-66,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金重点项目(20235020);中药药效组分指纹图谱分析方法的研究;负责人:梁逸曾;中国科学院知识创新工程重要方向项目(KGCX2-SW-213);基于现代理论和技术的复方中药系统研究;负责人:梁鑫淼。

摘　　要：本文采用组分中药的研究模式,以发展构建中药组分库为核心,选取葛根为研究对象, 探讨了组分的分离与表征方法。应用工业色谱及相关技术,发展了高效的规模组分制备分离方法,获取了18个正丁醇部位的制备组分。利用高效液相色谱,获取了18个组分化学指纹谱,与标准品对照,对组分进行了初步表征。In this study TCM components are taken for its model, the construction and development of TCM component library are regarded as its core and the root of kudzu is chosen as its object to explore the method for the separation and characterization of TCM components. As a result a method for efficient preparation and separation of scale components has been developed and 18 components from n-butyl alcohol fraction have been obtained due to the application of industrial chromatograph and other related techniques, and 18 fingerprints of component chemistry have been achieved by HPLC, which have been preliminarily characterized via comparison of them with standard ones.

关 键 词：葛根 组分库 葛根色谱图 工业色谱 高效液相色谱 

分 类 号：R282.71[医药卫生—中药学] R284.1[医药卫生—中医学]