高压氧综合治疗对严重烧伤患者血浆一氧化氮、内皮素-1含量的影响  

The effect of hyperbaric oxygenation therapy on the plasma levels of nitric oxide and endothelin-1 in severely burned patients

作　　者：李志才[1] 徐能武 张克[1] 孙曙光 郑莉 杨晓东 

机构地区：[1]解放军第九七医院高压氧科,江苏省徐州221004 [2]南京军区烧伤中心 [3]解放军第九七医院生化科,江苏省徐州221004

出　　处：《中华航海医学与高气压医学杂志》2005年第4期243-245,共3页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的研究严重烧伤患者血浆一氧化氮(NO)、内皮素-1(ET-1)含量的变化及高压氧(HBO)的影响。方法选择烧伤总面积(TBSA)≥30%或Ⅲ度面积≥10%的患者84例,分为高压氧组(HBO组)和非高压氧组(non-HBO组),分别于伤后10个时相点抽取静脉血,分别用硝酸还原酶法,放免分析法测定血浆NO,ET-1含量的变化。结果non-HBO组患者伤后各时相点平均血浆ET-1含量明显高于正常对照组(P<0.01),而NO的含量则显著降低(P<0.01);HBO组治疗后NO接近正常对照组(P>0.05),但ET-1显著低于non-HBO组(P<0.01)。结论严重烧伤患者血浆NO的降低及ET-1的升高参与烧伤后机体变化的全过程;HBO可显著改变严重烧伤患者血浆NO,ET-1含量,故对烧伤治疗有益。Objective To evaluate the concentration of nitric oxide （NO） and endothelin-1 （ET-1） in the plasma of severely burned patients and the effect of hyperbaric oxygenation （HBO） therapy on the changes of NO and ET-1 levels. Methods 84 patients with thermal injuries of more than 30% total body surface area or with more than 10% third-degree burn were randomly divided into HBO group （n =50） and non-HBO group （n = 34）. The venous blood samples were drawn at postburn 10 time points. The plasma concentration of NO and ET-1 were measured respectively by Griess methods and radioimmunoassay （ RIA ）. Results At each period post-burn,the plasma ET-1 level in non-HBO group was markedly higher than that in the control group,but the NO level was contrary. After HBO therapy, the plasma levels of NO and ET-1 in the HBO group changed apparently and the NO level was not significant .different from that of the control group, whereas the ET-1 level was remarkably lower than that in the non-HBO group . Conclusions The NO concentration in the plasma of severely burned patients decreased and the ET-1 concentration increased during all peridos post-burn. HBO therapy could enhance the NO plasma level and decrease the ET-1 level, which might be helpful in burn management.

关 键 词：高压氧 烧伤 一氧化氮 内皮素-1 

分 类 号：R644[医药卫生—外科学]