华心素颗粒治疗充血性心力衰竭多中心双盲双模拟临床应用  

Clinical Study on Treating CHF with HUAXINSU Granules by Polycentiric,Double Blind and Double Simulation.

作　　者：霍永芳[1] 张贞[1] 郭仕达[1] 凌隽[1] 

机构地区：[1]上海市第七人民医院,200137

出　　处：《中国自然医学杂志》2005年第4期291-292,共2页Chinese Journal of Natural Medicine

摘　　要：目的评价华心素颗粒治疗充血性心力衰竭的有效性和安全性。方法120例患者,随机分治疗组(华心素颗粒组)59例,对照组(地高辛组)61例。采用多中心、双盲、双模拟设计。观察治疗前后纽约心功能分级、西医症候计分、中医症候计分、生活质量计分及安全性指标的改变。结果经治疗后两组纽约心功能分级、西医症候计分、中医症候计分、生活质量计分均有显著改善,两组间差异无统计学意义。安全性指标无显著性改变。结论华心素颗粒可有效、安全地治疗充血性心力衰竭,效果与地高辛相当。Objective To evaluate effectivity and safety of treating CHF with HUAXINSU granules. Methods Divid 120 patients into two groups at random： HUAXINSU granules group, 59 patients, as treatment group, and digoxin group, 61 patients, as control group. By design of polycentric, double blind and double simulation, observe change of NYHA, western medicinal symptom score, Chinese medicinal symptom score, quality of life score and indexes of safety. Results There are significant changes in both two groups about NYHA, western medicinal symptom score, Clfinese medicinal symptom score and quality of life score after treatment, but no statistical significant changes between two groups. No significant changes in two groups about indexes of safety. Conclusion HUAXINSU granules can cure CHF effectively and safely, with same effect to digaoxin.

关 键 词：华心素颗粒 地高辛 充血性心力衰竭 

分 类 号：R541.61[医药卫生—心血管疾病] R259.892[医药卫生—内科学]