2型糖尿病患者慢性肺损伤的超微病理改变及临床意义  

THE CHANGES AND ITS CLINICAL SIGNIFICANCE OF ULTRASTRUCTURE IN LUNGS OF TYPE 2 DIABETIC PATIENTS

作　　者：张宏[1] 白景文[2] 于振涛[3] 谢云[1] 张秋梅[1] 窦红梅[1] 于德民[1] 

机构地区：[1]天津医科大学代谢病医院 [2]天津医科大学超微病理室 [3]天津医科大学肿瘤医院,天津300070

出　　处：《解剖学报》2005年第6期646-649,共4页Acta Anatomica Sinica

基　　金：天津医科大学自然基金项目资助(2001KY48)

摘　　要：目的探讨成人2型糖尿病患者肺组织超微结构的病理特点及临床意义。方法利用透射电镜观察10例2型糖尿病合并肺癌患者远离癌肿组织周围的肺组织活检标本。结果肺Ⅱ型肺泡细胞变小,表面微绒毛消失,嗜锇性板层小体萎缩,失去板层状结构,形成一高电子密度实心小团块;粗面内质网及线粒体均呈囊性扩张,内有透亮物质沉积,常染色质减少、异染色质凝聚;肺泡上皮和血管内皮间基膜弥漫性增厚,呈洋葱皮样改变,周围有蛋白质沉着并与基膜融合。结论肺为糖尿病慢性“攻击”的靶器官。糖尿病所导致的肺组织病理改变有不同于其他肺疾患的自身特点,是肺功能异常的病理基础。Objective To investigate the pathological characteristics and clinical significance of ultrasructure in lung tissues of type 2 diabetic adult patients. Methods Normal lung tissues far from lung neoplasm in 10 cases of type 2 diabetic patients associated with lung cancer were observed under a transmission electron microscope. Results Type Ⅱ alveolar cells became small, and cell superficial microvilli disappeared, Osmiophilic lamellar body became atrophy, lacked lameUar structure and formed a solid globule with high electrom dense; Rough endoplasmic reticulum and mitochodria in cytoplasm were enlarged cystiformly, and there were translucent materials deposited in vesicle, euchromatin decreased, heterochromatin condensed; The basement membrane of bronchial capillary were diffusely thickened and mostly showed onion-skin like change, protein deposited around and mixed with basement membrane. Conclusion Lung is confirmed to be the target organ of chronic damage in diabetes. Pathological changes of pulmonary tissues induced by diabetes have its specific characteristics, which are different from other pulmonary diseases. These changes are pathological basis of pulmonary function abnormalities.

关 键 词：2型糖尿病 肺损伤 Ⅱ型肺泡细胞 微血管基膜 透射电镜 

分 类 号：R587.1[医药卫生—内分泌]