藏族妇女维生素D受体基因BsmⅠ多态性与骨量无关  

No relationship between single nucleotide polymorphisms of vitamin D receptor gene and bone mass in Tibetan women

作　　者：王琦[1] 葛宝丰[1] 殷莹[1] 白孟海[1] 

机构地区：[1]兰州军区兰州总医院骨科研究所,730050

出　　处：《中华内分泌代谢杂志》2005年第6期535-536,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：全军医药卫生科研基金资助项目(01Z008)

摘　　要：测定藏族妇女维生素D受体基因BsmI单核苷酸多态性和跟骨定量超声参数。结果显示不同基因型组对应的定量超声参数差异无统计学意义,年轻妇女和绝经后妇女的基因型分布频率差异也无统计学意义,未发现藏族VDR基因的BsmI多态性与峰值骨量的获得和骨量丢失速率相关。The single nucleotide polymorphisms （SNP） of vitamin D receptor （VDR） gene were determined by Bsm Ⅰ restriction endonuclease analysis and quantitative ultrasonography indexes （QUI） of calcaneum were measured in Tibetan women. The results showed that there were no statistical differences between QUI of different genetypes and between distribution frequencies of gene types in young women and menopausal women. And it was found that the SNP of VDR by Bsml restriction endonuclease analysis was not relevant to bone mass acquisition and rate of bone mass loss.

关 键 词：受体 骨化三醇 多态性 单核苷酸 骨质疏松 定量超声 

分 类 号：R580[医药卫生—内分泌]