大黄酸对低剂量链脲佐菌素肥胖糖尿病大鼠糖尿病肾病的影响  

Rhein improves diabetic nephropathy in obese diabetic rats induced by low dose streptozotocin

作　　者：张学亮[1] 郭啸华[1] 刘志红[1] 周红[1] 王建平[1] 陈惠萍[1] 黎磊石[1] 

机构地区：[1]南京军区南京总医院,解放军肾脏病研究所

出　　处：《中华内分泌代谢杂志》2005年第6期563-565,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：用低剂量链脲佐菌素(25mg/kg体重)加高糖、高脂饲料喂养大鼠诱导肥胖糖尿病模型,用大黄酸(100mg·kg-1·d-1)进行预防性干预或治疗性干预,均显示大黄酸能降低低剂量链脲佐菌素肥胖糖尿病大鼠尿蛋白水平、抑制肾小球肥大、TGF-β1mRNA的高表达及改善肾脏病变。Low dose streptozotocin and high sucrose, high lard food-induced obese diabetic rats were treated with rhein. The results showed that rhein decreased urine protein excretion, inhibited glomerular hypertrophy and TGF-β1 mRNA overexpression, and ameliorated glomerular pathological change in the diabetic rats.

关 键 词：大黄酸 蛋白尿 转化生长因子Β 糖尿病肾病 形态学 

分 类 号：R285.5[医药卫生—中药学]