氯化3-氰-2-羟丙基三甲铵的拆分  

RESOLUTION OF THE 3-CYANO-2-HYDROXYPROPYL TRIMETHYLAMIN CHLORIDE

作　　者：张小林[1] 孙日圣[2] 姚彦红[2] 杨期勇[2] 

机构地区：[1]南昌大学基础化学实验中心,江西南昌330029 [2]南昌大学环境与化工学院,江西南昌330029

出　　处：《南昌大学学报（理科版）》2005年第6期526-528,532,共4页Journal of Nanchang University(Natural Science)

基　　金：江西省科技厅2000年工业攻关项目(Z-01707)

摘　　要：研究了利用N-乙酰-L-谷氨酸为拆分试剂,成功的对氯化3-氰-2-羟丙基三甲胺进行光学拆分,一次拆分光学纯度为92%,产率为37%;二次拆分光学纯度达95%,产率为29.1%。Optical resolution of the 3 - cyano - 2 - hydroxypropyl trithylamamin chloride using N - acetyl - L - glutamic acid as resolution agent was studied. Optical purity of resolution of L - 3 - cyano - 2 - hydroxypropyl trimethylamin chloride was 92%. The yield was 37%. Optical purity of its secondry purity was 95%. They yield was 29.1%.

关 键 词：光学拆分 N-乙酰-L-谷氨酸 氯化-3-氰-2-羟丙基三甲胺 L-肉碱 拆分试剂 羟丙基 氯化 三甲铵 氰 光学纯度 

分 类 号：TQ464.4[化学工程—制药化工] TQ352.7