硒化壳聚糖抗K562细胞的实验研究  

Inhibition of Selenium on Proliferation and Apoptosis of K562 Cell

作　　者：邓守恒[1] 孙各琴[2] 周有利[1] 邓守平[3] 毛达勇[1] 

机构地区：[1]郧阳医学院附属太和医院检验部,湖北十堰442000 [2]郧阳医学院基础医学院,湖北十堰442000 [3]郧阳医学院堰桥医院,湖北十堰442000

出　　处：《广东微量元素科学》2005年第11期18-20,共3页Trace Elements Science

摘　　要：用MTT法和AO/EB荧光染色法观察了硒化壳聚糖对K 562肿瘤细胞株生长的影响。结果发现,硒化壳聚糖可有效地抑制K 562细胞生长,并呈量效、时效关系。经硒化壳聚糖作用后的细胞可明显出现核固缩、碎裂等凋亡形态改变。硒化壳聚糖可诱导K 562细胞凋亡,抑制其生长。The effects of selenium on proliferation and apoptosis of K 562 cell were studied by MTr and AO/EB methods. The results showsed that selenium could inhibite the proliferation of K 562 obviously and induce K 562 cells apoptosis.

关 键 词：硒化壳聚糖 慢性粒细胞性白血病细胞 

分 类 号：R979.1[医药卫生—药品]