内皮素在慢性肾脏疾病诊断中的应用  

Observation on Changes of Endothelin in the Diagnosis of Use of Chronic Kidney Disease

作　　者：费梅[1] 熊佩华[1] 陈爱平[1] 张玲[1] 府剑英[1] 徐峰坡[2] 

机构地区：[1]苏州大学附属第一医院中西医结合科,江苏苏州215006 [2]苏州大学附属第一医院核医学科,江苏苏州215006

出　　处：《苏州大学学报（医学版）》2005年第6期1018-1019,1022,共3页Suzhou University Journal of Medical Science

基　　金：苏州大学附属第一医院院内资助研究课题(No:H04009)

摘　　要：目的探讨内皮素(ET)水平在慢性肾脏疾病发生、发展中所起的作用。方法采用放射免疫法对正常人和慢性肾脏疾病患者血浆、尿ET-1进行检测,同时测定其血肌酐(Scr)、尿β2-微球蛋白的值,计算肌酐清除率(Ccr)。结果各期慢性肾脏病患者血、尿ET-1、β2-MG均较正常人升高,差异有显著性意义(P<0.01)。β2-MG与Scr呈显著正相关(P<0.01),β2-MG与尿ET-1亦呈显著正相关(P<0.01)。血、尿ET-1均与Scr呈显著正相关(P<0.01),血ET-1与Ccr呈显著负相关(r=0.780,P<0.01),尿ET-1与Ccr呈显著负相关(r=0.888,P<0.01),且尿ET-1与Ccr相关性较血ET-1与Ccr相关性更强。结论尿ET-1与慢性肾脏病的发生、发展关系密切。Objective To study the significance of the changes of plasm, urinary endothelin （ET） in the occurrence, development of chronic kidney disease. Methods The levels of plasm, urinary ET- 1 by radio-immuno-assay in patients with chronic kidney disease and the normal subjects, and Scr,uri- nary β2-MG,Ccr were also tested. Results The level of plasm, urinary ET-1 and urinary β2-MG were higher than that in the normal subjects （P d0.01）. β2-MG was significantly correlated with Scr（P〈 0.01）, β2-MG was also significantly correlated with urinary ET-1 （P 〈 0.01）. Plasm and urinary ET- 1 were both correlated with Scr （P〈 0.01）, Plasm ET-1 and Ccr had negative correlation（ r = 0. 780, P 〈 0.01）, Urinary ET-1 and Ccr had also negative correlation（ r = 0. 888, P 〈 0.01 ）. Conclusion The urinary ET-1 level is sensitive to reflect the renal function change and the progress of the renal impairment.

关 键 词：慢性肾脏病 内皮素 内生肌酐清除率 Β2-微球蛋白 

分 类 号：R692[医药卫生—泌尿科学]