缝隙连接蛋白43基因及其辐射诱导表达反应  

Connexin43 gene and its irradiation-induced expression

作　　者：龙贤辉[1] 周平坤[2] 

机构地区：[1]南华大学公共卫生学院卫生毒理学教研室,衡阳421002 [2]军事医学科学院放射与辐射医学研究所,北京100850

出　　处：《国外医学（放射医学核医学分册）》2005年第6期269-271,共3页Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)

摘　　要：由缝隙连接蛋白构成的膜通道是相邻细胞间细胞通讯方式之一。缝隙连接蛋白是一超基因家族,其中缝隙连接蛋白43分布最为广泛,它在调控细胞增殖及分化、维持细胞内环境稳态、维护机体正常发育、血细胞形成等方面有着重要的生理功能。最新研究表明,低剂量电离辐射能诱导该基因高表达,由此,从分子水平揭示了细胞间通讯在低剂量辐射反应中的作用,而且缝隙连接蛋白43还有可能被发展成新的辐射损伤生物分子标记物。Gap junctions, composed of connexin protein subunits, provide the important channel for the intercellular communication. Connexin43, the most popular component of the connexin protein family, is widely expressed in multiple tissues and cell lines and plays an important role in cell proliferation, differention and tissue homeostasis. Recently it was reported that the expression of connexin43 gene is remarkedly up-regulated by low dose ionizing radiation, the available data suggest connexin43 gene to be a poten-tial sensitive bio-marker in radiation damage.

关 键 词：缝隙连接蛋白43 细胞间通讯 低剂量电离辐射 基因表达 

分 类 号：R818[医药卫生—放射医学]