铅和乙醇对雄性小鼠细胞免疫功能影响  

Effects of lead and ethanol on cell immunization in male mice

作　　者：赵剑[1] 蔡原[2] 谭成森[2] 翟玲玲[2] 周平[2] 

机构地区：[1]沈阳药科大学药学院安全评价中心,沈阳110003 [2]中国医科大学毒理教研室

出　　处：《中国公共卫生》2006年第1期52-53,共2页Chinese Journal of Public Health

摘　　要：目的探讨铅与乙醇对雄性小鼠细胞免疫的影响及其机制。方法检测铅与乙醇联合染毒的雄性小鼠脾脏器系数、T淋巴细胞增殖功能、丙二醛(MDA)生成量、还原型谷胱甘肽(GSH)含量。结果醋酸铅与乙醇联合组T淋巴细胞增殖功能降低,而脾组织MDA生成量则明显升高。结论铅与乙醇对雄性小鼠细胞免疫有协同损伤作用,并可能与脂质过氧化有关。Objective To study the effects and mechanism of lead and ethanol on the cell immunization of male mice. Methods The effects of lead and ethanol by the spleen visera coefficient were studied, T lymphocytes were determined by blastogenic response： imduced by the mitogen, concanavalin A （ConA）, of spleen lymphocyts as well as glutathione and lipid peroxidation of the spleen in the male mice. Results T lymphocytes were determined by blastogenic response imduced by the mitogen, concanavalin A （ConA） was decreased in all experimental groups. The content of LPO was increased in all experimental groups. Conclusion Lead and ethanol may affect the cell immunization of male mice with joint effect and could be related to the lipid peroxidation.

关 键 词：铅 乙醇 细胞免疫 脂质过氧化 

分 类 号：R994.6[医药卫生—毒理学]