心肌肌钙蛋白Ⅰ在小儿病毒性心肌炎中的诊断价值探讨  

Diagnostic Value of Cardiac Troponin I in Children With Viral Myocarditis

作　　者：李全礼[1] 都鹏飞[1] 

机构地区：[1]安徽医科大学第一附属医院儿科,合肥市230022

出　　处：《实用全科医学》2006年第1期11-12,共2页Applied Journal Of General Practice

摘　　要：目的探讨心肌肌钙蛋白I(cardiac troponin I,cTn I)在小儿病毒性心肌炎(viral myocarditis,VMC)中的诊断价值。方法采用ELISA法测定72例病毒性心肌炎患儿及50例非心脏疾患患儿的心肌肌钙蛋白I,并与肌酸磷酸激酶同工酶CK-MB比较。并将72例病毒性心肌炎患儿按病程、临床类型分组,进行组间比较。结果病毒性心肌炎患儿的cTnI(0.29±0.48)μg/L明显高于非心脏疾患患儿数(0.06±0.15)μg/L(P<0.01)。其特异性明显强于CK-MB,(P<0.05),且在发病2周以内者有较高的敏感性。结论cTn I是诊断小儿病毒性心肌炎中具有一定特异性的重要指标。Objective To study the diagnostic value of cardiac troponin Ⅰ （Ctn Ⅰ） in children with viral myocarditis （VMC）. Methods Serum Cth Ⅰ was detected by ELISA in 72 children with VMC and 50 controls without cardiopathy. We also compared serum Ctn Ⅰ with CK -MB in children with VMC. 72 children were divided into 4 groups according to course of disease, clinical type and serum Ctn Ⅰ ,CK-MB were compared among them. Results The level of serum Ctn v in children with VMC （0.29±0.48） was higher than that in children without VMC （0.06±0.15） （P〈0.01）. And the change of Cth Ⅰ was more specific than CK - MB （ χ^2 = 3.96, P 〈 0.05 ）. And Cth Ⅰ was more sensitive than CK - MB during 2 weeks after invasion. Conclusions Ctn Ⅰ is important and specific for diagnosis of VMC in children,

关 键 词：心肌肌钙蛋白Ⅰ 病毒性心肌炎 儿童 

分 类 号：R542.211[医药卫生—心血管疾病] R446.11[医药卫生—内科学]