药用微乳伪三元相图的几种制备方法比较研究  

Comparison among Several Preparation Methods for Pseudo-ternary Phase Diagrams of Pharmaceutical Microemulsions

作　　者：潘国梁[1] 贾晓斌[1] 魏惠华[2] 王勇[2] 

机构地区：[1]江苏省中医药研究院,南京市210028 [2]江苏大学,镇江市212013

出　　处：《中国药房》2006年第1期21-23,共3页China Pharmacy

基　　金：江苏省135工程重点人才资助项目(65RC2002065)

摘　　要：目的评价目前常用的几种微乳伪三元相图制备方法的优劣。方法选择吐温-80、聚氧乙烯辛基苯基醚(OP)和大豆卵磷脂为乳化剂,乙醇为助乳化剂,肉豆蔻酸异丙酯或油酸乙酯为油相,制备伪三元相图,以相图中数据点的准确性和可靠性等为指标,评价不同方法所得微乳相图的差异。结果不同方法制备的水包油型乳化剂的伪三元相图微乳区面积差异不大,但图中不同区域数据点的准确性和可靠性差异较大;不同方法制备的油包水型乳化剂伪三元相图的各相以及相区的面积差异均较大。结论制备准确可靠的伪三元相图,应根据组分的性质及所制备的微乳类型来选择方法,并综合利用某几种方法来判断滴定终点。OBJECTIVE ： To evaluate and compare the current preparation methods for pseudo - ternary phase diagrams of pharmaceutical microemulsions. METHODS： Pseudo- ternary phase diagrams were prepared by using Tween - 80, OP and lecithin as emulsifiers respectively, alcohol as assistant emulsifiers, isopropyl myristate or aethylis oleas as the oil phase, the difference in phase diagrams obtained with different preparation methods was compared with regard to the accuracy and authenticity of valid point. RESULTS： To O/ W surfactant, difference in the area of phase diagrams was small, but the distinction of accuracy and authenticity of valid point was great. To W/O surfactant, difference in the area of phase diagrams was great. CONCLUSION： It is recommended to select the preparation method according to the characteristics of the constituents and the types of microemulsions in order to establish accurate and dependable phase diagram, the end point of titration should be judged comprehensively.

关 键 词：伪三元相图 微乳 乳化剂 助乳化剂 制备方法 

分 类 号：R943[医药卫生—药剂学]