肿瘤显像剂^(18)F-氟代乙酸盐的自动化合成  

Automated synthesis of ^(18)F-fluoroacetate as tumor imaging agent

作　　者：唐刚华[1] 唐小兰[2] 王明芳[1] 罗磊[1] 甘满权[1] 

机构地区：[1]南方医科大学南方医院核医学科PET中心,广州510515 [2]华南农业大学理学院,广州510642

出　　处：《核技术》2006年第1期59-62,共4页Nuclear Techniques

基　　金：广东省科技计划资助项目(2003C34304);南方医科大学南方医院院长基金资助项目(991015)

摘　　要：为研究肿瘤显像剂18F-氟代乙酸盐(18F-FAC)的自动化合成工艺,采用“一锅法”和TRACERlabFXF-N自动化合成装置,以溴代乙酸苄酯为前体,在同一反应瓶中经亲核氟化、NaOH水解两步反应及HPLC系统分离纯化制备18F-FAC注射液。总合成时间约50min,未校正放化产率和放化纯度分别大于45%和99%。采用“一锅法”自动化合成18F-FAC,操作简便,能满足科研和临床正电子发射断层显像的需要。To improve the automated synthesis technology of ^18F-fluoroacetate （^18F-FAC） as tumor imaging agent, the one-pot procedure at TRACERlab FXF-N module was tried. ^18F-FAC injection was obtained via a two-step reaction including nucleophilic fluorination of the precursor benzyl bromoacetate with ^18F-fluoride and subsequent hydrolysis of the protecting group with 3 mol/L NaOH at the same reaction vessel, and purification with HPLC system, ^18F-FAC was automatically synthesized with an uncorrected radiochemical yield of more than 45% and radiochemical purity of more than 99% in the synthesis process of about 50 min. ^18F-FAC injection is easy to be obtained and can be used for clinical and scientific study with positron emission tomography （PET） imaging.

关 键 词：^18F-氟代乙酸盐 肿瘤显像剂 自动化合成 

分 类 号：R817.4[医药卫生—影像医学与核医学]