胃炎消对胃癌癌前病变bcl-2癌基因mRNA表达的影响  

Effect of "Wei Yan Xiao" on bcl-2 Oncogene mRNA Expression in Precancerous Lesion of Gastric Cancer

作　　者：胡玲[1] 劳绍贤[1] 王建华[1] 

机构地区：[1]广州中医药大学脾胃研究所,广东广州5104005

出　　处：《上海中医药杂志》2006年第1期27-28,共2页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家"八五"攻关项目(85-919-01-01);广州中医药大学科学研究与发展总体规划重点项目(GH0016)

摘　　要：观察胃炎消对胃癌癌前病变(PLGC)的治疗作用及其对PLGC组织中bcl-2凋亡相关癌基因表达的影响。方法:采用随机双盲法,将40例PLGC患者分为治疗组(胃炎消治疗)25例和对照组(维酶素治疗)15例,治疗前、后胃黏膜活检标本采用原位分子杂交标记法作bcl-2癌基因mRNA转录水平的检测。结果:治疗组临床总有效率为84.00%,病理疗效以中度异型增生为好,作用优于对照药(P"0.05);治疗组患者治疗后bcl-2癌基因mRNA转录水平表达下调(P"0.05)。结论:胃炎消对PLGC有良好的治疗作用,其机制可能与下调PLGC组织中bcl-2癌基因mRNA转录水平的表达有关。To observe the tkerapeutic effect of Weiyanxiao（WYX）on precancerous lesions of gastric cancer（PLGC）and its regulating effect of mRNA expression of bcl-2 oncogene in PLGC tissues.Methods：Forty patients with endoscopically andpathologically confirmed PLGC were studied.Among them 25 patients were treated with WYX,and 15 patients with Weimeisu （WMS）as control.mRNA expression of bcl-2 oncogene was detected by in situ hybridizationhistochemical methods before and after treatment. Results：The therapeutic effect clinical syndromes and moderate dysplasia in WYX group were better than that in WMS group. The overexpression of bcl-2 oncogene at mRNA stage were found in PLGC,and gradually increased with the progress of lesions.WYX could reduced the expressions of bcl-2 oncogene at mRNA stage in PLGC tissues to some extent.Conclusion：WYX has better therapeutic effect on PLGC, And this effect may be interrelated with regulating effect of WYX on the mRNA expression of bcl-2 oncogene that related with apoptosis.

关 键 词：胃肿瘤 癌前病变 中医药疗法 BCL-2基因表达 

分 类 号：R273[医药卫生—中西医结合]