镉对未成年雌性小鼠子宫增重作用的剂量-效应关系  

Study of the Dose-effect Relation of Cadmium on the Weight-increase of Premature Female Mice's Womb

作　　者：何庆峰[1] 张文昌[1] 黄雅卿[1] 李宏[1] 林寿余[1] 

机构地区：[1]福建医科大学公共卫生学院,福州市350004

出　　处：《职业与健康》2006年第2期104-105,共2页Occupation and Health

摘　　要：目的通过研究镉对未成年小鼠子宫增重作用的剂量-效应关系,为探讨镉的雌激素样活性提供实验依据。方法将64只未成年雌性昆明种小鼠按体重分层,随机分为8组(阴性对照组,雌二醇阳性对照组和1.25、5、20、80、320、1 280μg/kg氯化镉剂量组),采用腹腔注射染毒方法,每天注射1次,注射容积为0.25 ml/10(g.d),连续注射3 d,最后1次腹腔注射24 h后称重,颈椎脱臼处死小鼠,取子宫称重。结果各染镉剂量组子宫增重与阴性对照组比较,差异无显著性(P>0.05),雌二醇阳性对照组子宫增重显著(P<0.05),实验中各染镉剂量与子宫脏器系数之间无剂量-效应关系。结论在该实验镉剂量范围内,未检测到镉对未成年雌性小鼠子宫有增重作用。[Objective] To study the dose - effect relation of cadmium on the weight - increase of premature female mice＇ s womb, and provide experimental basis for exploring the estrogen - like activity of cadmium. [Methods] 64 mice were randomly divided into 8 groups, namely, negative control group, positive estradiol control group and 6 cadmium chloride dose groups with doses of 1. 25, 5, 20, 80, 320 and 1 280 μg/kg respectively. After 3 days＇ celiac injections, the mice were killed and their wombs were weighted. [Results] No significant difference was found in the womb weight between the cadmium chloride groups and the negative control group （ P 〉 0.05）; while the positive estradiol control group showed significant difference in the weight - increase of the womb （ P 〈 0.05 ）. There is no dose - effect relation between the cadmium doses and the coefficient of womb organ. [ Conclusion] No weight - increase effect was detected in cadmium on the oremature female mice within the experimental dose range of cadmium.

关 键 词：镉 雌激素样作用 剂效反应关系 子宫增重试验 

分 类 号：R114[医药卫生—卫生毒理学]