息痛颗粒替代给药对吗啡依赖大鼠戒断症状的影响  

Effect of Xitong granule with substitutive treatment on withdrawl responses in morphine -dependent rats

作　　者：郭洪涛[1] 杨万雷[2] 高远[2] 

机构地区：[1]周口市中心医院放疗科,河南周口466000 [2]郑州大学基础医学院药理教研室,河南郑州450052

出　　处：《新乡医学院学报》2006年第1期29-30,共2页Journal of Xinxiang Medical University

摘　　要：目的了解息痛颗粒有无类似吗啡样药物依赖性潜力。方法对以剂量递增法形成之吗啡依赖性大鼠,替之以息痛颗粒(30、15、1g·kg-1·d-1)灌胃给药,连续3d,以吗啡作为阳性对照药,观察戒断症状及体重变化。结果息痛颗粒替代给药各组动物戒断症状明显,体重显著下降,而吗啡组动物戒断症状及体重均无明显改变。息痛颗粒组大鼠与吗啡组相比,戒断症状分值显著增高(P<0.01)。结论息痛颗粒对吗啡依赖大鼠的戒断症状,无替代作用。Objective To evaluate the dependence-producing potential of Xitong granule. Methods The withdrawl responses and body weight loss were observed in morphine-dependent rats after the oral administration of Xitong granule at doses of 30,15 and 1.0 g· kg^-1· d^-1 for 3 days, morphine as positive drugs. Results There were significarit differences in total scores of symptoms and weight loss between Xitong treated groups and morphine group. Conclusion Xitong granule have no significant effect on the withdrawl symptoms in morphine-dependent rats.

关 键 词：息痛颗粒 吗啡依赖大鼠 替代给药 

分 类 号：R965[医药卫生—药理学]