3种兽药及饲料添加剂对鱼类的毒理效应  

Toxicological Effects of Three Veterinary Drugs and Feed Additives on Fish.

作　　者：李兆利[1] 陈海刚[1] 徐韵[1] 孔志明[1] 

机构地区：[1]污染控制与资源化研究国家重点实验室/南京大学环境学院,江苏南京210093

出　　处：《生态与农村环境学报》2006年第1期84-86,共3页Journal of Ecology and Rural Environment

基　　金：高等学校博士学科点专项科研基金(20020284041)

摘　　要：采用斑马鱼、鲤鱼作为生物材料,通过斑马鱼急性毒性试验、胚胎发育试验和鲤鱼肾细胞单细胞凝胶电泳试验,分别从生物个体水平、细胞水平和分子水平,对兽药及饲料添加剂喹乙醇、阿散酸和土霉素进行了生态毒理学效应研究。急性毒性试验结果表明,3种兽药及饲料添加剂在有生态学意义的浓度范围内对斑马鱼的急性毒性均不大;胚胎发育试验结果表明,喹乙醇和阿散酸对斑马鱼胚胎发育72 h的EC50值分别为221.20和239.54 mg.L-1,具有明显的致畸效应;单细胞凝胶电泳试验结果表明,喹乙醇和土霉素均具有一定的遗传毒性,能引起鲤鱼肾细胞DNA的明显损伤,并呈现出一定的剂量-效应关系。Olaquindox, arsanilic acid,and oxytetracycline are three common kinds of veterinary drugs and feed additives. Their eco-toxicological effects on zebrafish（ Brachydanio rerio）and carp（ Cyprinus carpio）were studied through acute toxicity test,and embryo test of zebrafish,and single kidney cell gel electrophoresis test（SCGE）in vivo of carp. Results show that acute toxicities of the three substances were not significant at concentrations of the ecological sense;olaquindox and arsanilicacid showed a significant teratogenic effect on the embryo, olaquindox and oxytetracycline could bring about obvious great DNA damage to carp kidney cells in vivo and have potential genotoxicity to fish.

关 键 词：喹乙醇 阿散酸 土霉素 毒理效应 斑马鱼 鲤鱼肾细胞 

分 类 号：X503.225[环境科学与工程—环境工程] X592