原发性高血压及糖尿病患者动脉硬化指数检测的意义  

Significance of arteriosclerotic index detection in patients with essential hypertension and diabetes mellitus

作　　者：张明华[1] 刘国树[1] 覃秀川[1] 刘蓉[2] 

机构地区：[1]解放军总医院南楼二科,北京市100853 [2]解放军总医院门诊内科,北京市100853

出　　处：《中国临床康复》2005年第47期40-42,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：目的比较单纯高血压与合并高脂血症和冠心病、脑血管疾病高血压患者及单纯糖尿病与糖尿病伴高血压患者间动脉硬化指数差异,并与健康者进行比较,同时分析影响动脉硬化指数的因素。方法①选择2004-04/2004-09解放军总医院门诊内科患者226例。按照患者的诊断结果将其分为5组单纯高血压组51例(男25例,女26例),高血压伴高脂血症组53例(男23例,女30例),高血压伴冠心病和/或脑血管病组53例(男22例,女31例),单纯糖尿病组21例(男14例,女7例),糖尿病伴高血压组48例(男27例,女21例)。选择同期本院健康体检者50人为健康对照组(男34例,女16例)。均对检测项目知情同意。②采用Cardio Vision M S2000动脉硬化测量仪在上午800/1100检测受试对象的动脉硬化指数、血压、脉压和心率。受试者安静休息5～10m in,坐位取右上臂测量,由指定的专业人员操作,测量3次,取其平均值作为最后的测定结果。并测量受试对象的身高、体质量,记录一般情况。③所有参数经正态性检验,动脉硬化指数不符合正态分布,余参数均为正态性分布。动脉硬化指数经倒数转换,即动脉硬化指数的倒数,转变为正态分布。采用t检验进行组间比较,Pearson相关系数进行相关分析。结果单纯高血压患者51例,高血压伴高血脂症患者53例,高血压伴冠心病和/或脑血管病患者53例,单纯糖尿病患者21例,糖尿病伴高血压患者48例,健康体检者50人均进入结果分析。①高血压伴冠心病和/或脑血管病组和糖尿病伴高血压组患者的动脉硬化指数明显高于健康对照组(P<0.01)。高血压组、高血压伴高脂血症组以及糖尿病组的动脉硬化指数与健康对照组比较,差异不明显(P>0.05)。②动脉硬化指数的倒数与年龄、收缩压和脉压呈显著负相关(r=-0.534,-0.544,-0.768,P<0.01);与舒张压呈显著正相关(r=0.185,P<0.01),与体质量指数和心率无明显相关性(r=-0.01AIM： To compare differences of arteriosclerotic indexes among patients with essential hypertension, hypertension accompanied by hyperlipemia, hypertension accompanied by coronary heart disease and cerebrovascular disease, essential diabetes and diabetes accompanied by hypertension, and compare with healthy people. Meanwhile, analyze the influencing factors of arteriosclerotic index. METHODS： （1） 226 patients from Clinic of Internal Medicine, General Hospital of Chinese PLA from April to September 2004 were divided into 5 groups according to their clinical diagnoses： Essential hypertension group （n =51）, hypertension accompanied by hyperlipemia group （n=53）, hypertension accompanied by coronary heart disease and/or cerebrovascular disease （n=53）, essential diabetes group （n=21）, diabetes accompanied by hypertension group （n=48）. Fifty healthy examinees of the same time were selected as normal control group （34 males and 16 females）. All participants knew and agreed the detecting items. （2） Arteriosclerotic index, blood pressure, pulse pressure and heart rate of subjects were detected at 8：00 AM and 11：00 AM respectively with Cardio Vision MS 2000 arteriosclerotic measuring instrument. Left upper arms of subjects were measured 3 times by professionals after 5 to 10 mins＇ rest, and the average value was taken as determinating results. Meanwhile, body height and body mass of subjects were measured and recorded. （3）All the parametes were tested for normality, and all parametes except arteriosclerotic index were in normal distribution. Reciprocal of arteriosclerotic indexes were in normal distribution, t-test was used to compare among groups, and correlation analysis was done in correlation coeffcient. RESULTS： Fifty-one patients with essential hypertension, 53 patients with hypertension accompanied by hyperlipemia, 53 patients with hypertension accompanied by coronary heart disease and/or cerebrovascular disease, 21 patients with essential diabetes, 48 patients with di

关 键 词：高血压 糖尿病 非胰岛素依赖型 动脉硬化 

分 类 号：R544.1[医药卫生—心血管疾病]