卡托普利对血管平滑肌细胞结构和钙的影响  

Effect of captopril on structure and Ca^(2+) of vascular smooth muscle cells

作　　者：齐建华[1] 章鲁[1] 王军[1] 顾培坤[1] 黄明智[1] 金正钧[1] 王新明[1] 

机构地区：[1]上海第二医科大学药理教研室,计算机医学应用教研室,上海市高血压研究所,中国科学院上海细胞生物学研究所血液血管研究室

出　　处：《中国药理学通报》1996年第3期229-232,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金;上海市高教局.No93CB30部分资助

摘　　要：为调查卡托普利（Ｃａｐ）的特殊血管效应和探讨其机制，用电镜和图象技术观察口服Ｃａｐ对自发性高血压大鼠（ＳＨＲ）主动脉平滑肌细胞（ＡＳＭＣ）超微结构和Ｃａ２＋的影响。用Ｃａｐ治疗ＳＨＲ１６ｗｋ，降低主动脉中膜厚度（１０４．７±６．６μｍｖｓ１３５．７±８．１μｍ）和改善ＡＳＭＣ的异常超微结构征象如异形核、线粒体肿胀和管状结构扩张以及降低ＡＳＭＣＣａ２＋浓度。故Ｃａｐ有阻止ＳＨＲ主动脉中膜肥厚和改善ＳＨＲＡＳＭＣ异常性超微结构的特殊血管效应。而降ＡＳＭＣＣａ２＋可能部分与它的特殊效应有关。The effect of oral captopril(Cap)on the ultrastructure and intracellular Ca2+([ Ca2+] i)Of aortic Smooth muscle Cells(ASMC)from spontaneously hypertensive rats(SHR)was investigated and its mechanism responsible its particular effect on blood vessel was evaluated by using transmission electron microscope and digital image processing technique.16 wk of treatment with Cap lessened medial thickness of aortae(104.7±6.6 vs 135.7±8.1μm)and abnormal ultrastructural signs of ASMC from SHR including heterogeneous population of nuclei,swelling of mitochondria and tubular systems as Well as decreased [Ca2+] i in ASMC.Cap possesses particular effect on blood vessel in preventing aortic medial thickness and improving of abnormal ultrastucture,which may be in part associated with a fall in [ Ca3+] i in ASMC.

关 键 词：胸主动脉 钙 卡托普利 超微结构 平滑肌细胞 

分 类 号：R972.4[医药卫生—药品] R965[医药卫生—药学]