青心酮对妊高征模型兔血浆纤溶相关因子和血小板功能的影响  

Effects of DHAP on plasma fibrinolytic related factors and blood platelet function in rabbit model for pregnancy-induced hypertension

作　　者：闪珍珍[1] 李郁[1] 熊承良[1] 吴熙瑞[1] 

机构地区：[1]同济医科大学生殖医学中心

出　　处：《中国药理学通报》1996年第3期244-246,共3页Chinese Pharmacological Bulletin

摘　　要：采用缩窄腹主动脉下段的方法造成家兔实验性妊高征模型，并采用比浊法和发色底物分解产色法检测了注射青心酮（３，４－Ｄｉｈｙｄｒｏｘｙａｃｅｔｏｐｈｅｎｏｎｅ，ＤＨＡＰ）的模型兔血小板聚集性（ＰＡｇ）、血浆组织型纤溶酶原激活物（ｔＰＡ）及其抑制物（ＰＡＩ－１）活性。结果显示ＤＨＡＰ可显著降低模型兔ＰＡｇ；对血浆ＰＡＩ－１活性的抑制作用明显强于对ｔＰＡ的作用，因此，ＤＨＡＰ对血小板功能和血纤溶活性的作用可能是其改善子宫胎盘血循环的作用机制之一。An animal model for pregnancyinduced hypertension(PIH) was produced in pregnant rabbits by constricting the aorta below the renal arteries and the effects of 3,4-Dihydroxyacetophenone(DHAP)on the activity of tPA and PAI-1 and blood platelet aggregation (PAg) were investigated by spedal substrata decomposition method and Born's method respectively. The results showed that the PAg of the rabbits decreased significantly by DHAP,the inhibitory effect on tPA activity was stronger than that on PAI-1. Therefore, the effects of DHAP on platelet function and the blood fibrinolysis might be the important mechanism in the improvement of utero-placental circulation by DHAP.

关 键 词：青心酮 妊高征 纤溶酶原激活物 抑制物 

分 类 号：R972[医药卫生—药品] R714.246[医药卫生—药学]