红花黄色素大鼠在体肠吸收动力学研究  

STUDIES ON THE INTESTINAL ABSORPTION KINETICS OF SAFFLOW YELLOW IN RATS

作　　者：宋洪涛[1] 张跃新[2] 郭涛[2] 康鲁平[1] 谢彤[3] 陈大为[3] 何仲贵[3] 

机构地区：[1]沈阳军区总医院药学科 [2]沈阳药科大学药学院 [3]福州总医院药学科

出　　处：《福州总医院学报》2005年第4期223-225,共3页Journal of Fuzhou General Hospital

基　　金：国家自然科学基金(30200363);辽宁省博士启动基金(2001102042)

摘　　要：目的:研究红花黄色素在大鼠各肠段的吸收动力学特征。方法:采用大鼠在体肠段灌流实验,主要从药物浓度、pH值、吸收部位等3方面对红花黄色素的肠段吸收特性进行研究。结果:在5μg·mL^(-1)～20μg·mL^(-1)浓度范围内药物浓度对吸收速率常数无影响;在pH7.8～pH5.4内药物吸收不受pH值影响;各肠段的吸收速率常数按空肠、十二指肠、回肠、结肠顺序依次下降,分别为0.1116,0.0753,0.0739,0.0185h^(-1)。结论:药物吸收符合一级动力学特征,吸收机制为被动扩散。Objective： To investigate the absorption characteristics and mechanism of safflow yellow for various intestinal segment. Method： The intestine in rats was cannulatod for in situ recirculation. The effects of drug concentration, pH value and absorption site on safflow yellow absorption were studiod. Results： The concentrations of safflow yellow from 5μg·mL^-1 to 20μg·mL^-1 and the pHof drug solution from pH 7.8 to pH 5.4 had no distinctive effect on the absorption kinetics. The absorption rate constant （Ka） were 0.1116, 0.0753, 0.0739, 0.0185h^-1, at jejtmum, duodenum, ileum and colon, respectively. Conclusion： The absorption of safflow yellow was a first-ordar process with the passive diffusion mechanism.

关 键 词：红花黄色素 吸收动力学 小肠 

分 类 号：R977.15[医药卫生—药品] R285.5[医药卫生—药学]