2-托品醇立体异构体的选择性合成  

Stereoselective synthesis of isomeric 2tropanols

作　　者：王林[1] 恽榴红[1] 张其楷[1] 

机构地区：[1]军事医学科学院毒物药物研究所

出　　处：《军事医学科学院院刊》1996年第2期81-84,共4页Bulletin of the Academy of Military Medical Sciences

摘　　要：以２托品酮外消旋体（１），分别经氧化铂催化氢化和金属钠还原，立体选择性制备２α和２β托品醇，再经左旋和右旋酒石酸拆分，得１Ｒ（５Ｓ），２Ｒ；１Ｓ（５Ｒ），２Ｓ；１Ｓ（５Ｒ），２Ｒ和１Ｒ（５Ｓ），２Ｓ托品醇四个光学异构体。The isomeric 2α(±) and 2β(±)tropanols were prepared stereoselectively from 2(±)tropanone by hydrogenation over platium oxide and reduction with metallic sodium respectively. The optical resolutions were carried out by (+) and (-) tartaric acid into four enantiomers and the configurations were assigned to 1R(5S), 2R; 1S(5R),2S; 1R(5S),2S and 1S(5R),2Rtropanols by comparing with that of the product degraded from L(-)cocaine.

关 键 词：2-托品醇 立体异构体 异构体 合成 抗胆碱药 

分 类 号：R971.92[医药卫生—药品] R914.5[医药卫生—药学]