卡托普利对高血压大鼠血小板内游离钙和血小板功能的影响  

The effect of Captopril on platelets cytosolic free calcium and platelets aggregation in renovascular hypertensive rats

作　　者：李华林[1] 林敬明[1] 胡莲[1] 魏向荣[2] 

机构地区：[1]广州珠江医院心内科,广州510282 [2]上海第二医科大学,95博信箱上海200025

出　　处：《中国药理学通报》1996年第2期138-139,共2页Chinese Pharmacological Bulletin

摘　　要：本文建立二肾一夹型肾血管性高血压大鼠(2KIC-RHR)动物模型,观察大鼠在高血压稳定期血小板胞浆内游离钙浓度([Ca^(2+)]_i)及血小板聚集率(PAg)的变化并研究了ACEI—卡托普利对高血压大鼠血小板内[Ca^（2+）]_i及血小板聚集功能的影响.结果发现:高血压大鼠血小板内[Ca^（2+）]_i及血小板聚集率均显著升高(P<0.01),卡托普利显著降低血压同时血小板内[Ca^（2+）]_i、血小板聚集率也明显减小(P<0.01).提示:2KIC—RHR在高血压稳定期存在血小板内钙代谢异常和血小板功能的改变,血小板活性的降低可能参与卡托普利的降压作用.To evaluate effects and mechanism of Captopril on BP of 2 -kidney, 1 -clip reno-vascular hypertensive rats ( 2K1C - RHR ), Platelets cytosolic free calcium, concentration ([Ca2+]i) and platelets aggregation (PAg) are measured. The results are as follows: [Ca2+ ]; and PAg increase significantly (P<0. 01); Captopril has obvious antihypertension, with [Ca2+]i and PAg decreasing markedly (P<0.01).These indicate that there is abnormality of intracellular calcium and platelets activity during sustain period of hypertension in the 2K1C -RHR. Moreover, the antihypertension of Captopril may attribute to regression of platelets activity.

关 键 词：高血压 血小板 细胞内钙 卡托普利 大鼠 

分 类 号：R972.4[医药卫生—药品] R544.1[医药卫生—药学]