促甲状腺激素释放激素对大鼠内毒素性休克的影响  

Effect of thyrotropin-releasing hormone (TRH) on endotoxic shock in rats

作　　者：吴勇杰[1] 杨庆利[1] 孟富敏[1] 李新芳[1] 常珍梅 

机构地区：[1]兰州医学院药理学教研室,兰州730000 [2]兰州市卫生学校,兰州730000

出　　处：《中国药理学通报》1996年第2期149-151,共3页Chinese Pharmacological Bulletin

摘　　要：研究了不同剂量TRH(促甲状腺激素释放激素)对大鼠大肠杆菌内毒素性休克的影响,并与纳洛酮进行比较.发现低(0.22mg·kg^(-1),iv)、中(0.67mg·kg^(-1),iv)、高(2mg·kg^(-1),iv)剂量的TRH均能迅速纠正内毒素性低血压,且明显提高大鼠24h存活率.2mg·kg^(-1)纳洛酮的升压效应与低剂量TRH相当,但前者在较低血压水平上提高大鼠存活率的作用更强,此点与TRH不同.The effect of TRH on endotoxic shock in rats was studied, iv 0. 22-2 mg ?kg-1 TRH significantly reversed hypotension induced by iv coli E. endotoxin (40 mg ?kg-1) into rats and caused a 4. 2 kPa rise in mean arterial pressure (MAP). MAP after TRH administered could be stablized over a higher level than control for 30 min and maintained for 3 h during observation. Interestingly enough, the MAP rose gradually in TRH-treated rats as contrast with increasingly falling of that in control group during the late shock. TRH also improved 24 h sur-vival of shock rats. The dose-response relationship could be observed between 0. 22 ~0. 67 mg ?kg-1 TRH and disappeared over a highest dose (2 mg ?kg-1). It was shown that the best dose to reverse hypotension and to improve survival was 0. 67 mg ?kg-1 TRH. Naloxone 2 mg ?kg-1 showed the nearly same effect as 0. 22 mg ?kg-1 TRH in increasing MAP, but the former had higher 24 h survival of rats than the later.

关 键 词：促甲状腺激素 释放激素 大鼠 内毒素性 休克 

分 类 号：R977.14[医药卫生—药品]