3—[4—(2,3—环氧丙氧基)苯基]丙酸甲酯的合成  

Synthesis of Methyl 3-[4-(2,3-Epoxypropoxy)phenyl] propionate

作　　者：欧阳志强[1] 张小林[2] 唐彬[1] 

机构地区：[1]南昌大学理学院,南昌330047 [2]南昌大学基础化学实验中心,南昌330047

出　　处：《江西化工》2005年第4期81-86,共6页Jiangxi Chemical Industry

摘　　要：对羟基苯丙酸甲酯与环氧氯丙烷,以碳酸钾为催化剂,PEG400为助催化剂,回流反应24小时,制得标题化合物,收率45%,产物径1HNMR,13CNMR,IR确认。研究表明,要获取高产率,环氧氯丙烷应大大过量。一旦回流平稳,反应即按相同的机理进行。PEG400的加入可大大增加目标化合物的含量,同时大大降低产物中羟基化合物的含量,使提纯步骤易于进行。Through the 24 hour reflux reaction of methyl 4 - hydroxybenzoate with epichlorohydrin, using potassium carbonate as catalyst, PEG400 as eoeatalyst, the title compound is synthesized with 45 % yield. The product is characterized by HNMR, CNMR, and 1R. The research shows that, epichlorohydrin should be largely excessive in order to get high product ratio. Once reflux become steady, the reaction would proceed with same mechanism. The addition of PEG400 can greatlyelevate the component of target compound and reduce that of the oxy - compound in the product, making the purification process easy.

关 键 词：3-[4-(2 3-环氧丙氧基)苯基]丙酸甲酯 艾司洛尔 中间体 制备 

分 类 号：TQ245.24[化学工程—有机化工]