Fas在妊娠过程中表达变化的研究  

The study on the Fas' expression during normal and HDCP.

作　　者：欧阳珊[1] 乔福元[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科,武汉430030

出　　处：《中国优生与遗传杂志》2006年第1期54-55,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨Fas在正常妊娠过程及妊娠期高血压疾病(HDCP)中的表达变化及意义。方法分别选取正常妊娠早期和晚期及HDCP胎盘绒毛组织。采用免疫组织化学方法检测Fas表达,并用高清晰彩色病理图像分析系统对其表达进行分析。结果Fas在妊娠早期胎盘组织中极少表达,妊娠晚期胎盘组织中表达增高。HDCP胎盘组织中Fas表达明显升高,与前两组比较差异有极显著性(P<0.01)。结论孕早期滋养细胞表面Fas表达在母胎免疫耐受中发挥重要作用,孕晚期Fas表达增加可能是引起HDCP的原因之一。Objective： To study the transformation of Fas＇expression during normal pregnancies and HDCP. Methods： Placenta tissues were obtained from the first and third trimester of normal pregnancy and HDCP. Immuno - histochemistry was used to investigate the expression of Fas. Highly precise color - image measure system for immuno - chemistry was taken advantage for quantitative analysis. Results ： The expressions of Fas in placentas of the first trimester were very little, and raised with the progress of pregnancy. In HDCP cases , the levels of Fas were obviously higher than normal pregnancies, Conclusion： In the first trimester of pregnancy, the expression of Fas on the surfaces of placental trophoblasts plays an important role in maternal - fetal immune tolerance , and increased expression of Fas in the third trimester may be one of the reasons of HDCP.

关 键 词：妊娠 妊娠并发症 心血管 免疫耐受 凋亡 

分 类 号：R714.1[医药卫生—妇产科学]