雄激素补充对中老年部分睾酮缺乏综合征中伴发抑郁症的治疗观察  

Observation of treatment with sndrogen supplement in partial androgen deficiency in the aging male accompanied with depression

作　　者：高天[1] 蔡华杰[1] 王承勇[2] 

机构地区：[1]上海交通大学医学院附属仁济医院老年病科,上海200001 [2]复旦大学附属中山医院内科

出　　处：《中国男科学杂志》2006年第1期46-48,共3页Chinese Journal of Andrology

摘　　要：目的探讨中老年部分睾酮缺乏综合征(PADAM)与中老年抑郁症的关系。方法对PADAM量表测评为PADAM的病人另给予抑郁自测量表(SDS)测评,SDS评分增高者分成治疗与对照二组,治疗组给予十一酸睾酮(安特尔)胶囊口服。每2周门诊随访一次,观测抑郁症状的变化及服用后有无副作用。3个月后,予两个表复测评估。结果除PADAM症状明显缓解外,抑郁症状明显改善,全部SDS的评分均明显下降,与服用雄激素之前有明显差异。结论中老年抑郁症与PADAM明显相关,服用雄激素补充后抑郁症状明显改善。Objective To probe into the relationship between PADAM （Partial androgen deficiency in the aging male） and depression in elderly. Methods Patients evaluated as PADAM using a PADAM scale were given extra evaluation for depression using a SDS （Self-Rating Depression Scale, Zung 1965）. Those whose SDS scores have grown high were divided into treatment group and control group. The treatment group was given orally testosterone undecanoate （Andriol）. They were required for follow-up once 2 weeks in OPD for observation of changes of depression symptoms and the presence of any side-effects after administration. 3 months later a repeated evaluation of the two scale were made, Results Beside the obvious relief of PADAM symptoms, depression symptoms significantly improved with an obvious drop of all SDS scores and an obvious difference as compared with pre-administration of androgen. Conclusion Depression in elderly are significantly associated with PADAM and there is an obvious improvement in depression symptoms with androgen supplementation therapy.

关 键 词：雄激素 PADAM 抑郁症 

分 类 号：R588[医药卫生—内分泌]