蛋氨酸与小鼠移植性肿瘤生长及抗癌药作用的关系  

THE INFLUENCE OF METHIONINE ON THE GROWTH OF TUMOR IN MICE AND ON ANTITUMOR ACTIVITY OF DRUGS

作　　者：谢冰芬[1] 潘启超[1] 陈海英[1] 潘伟光[1] 冼励坚[1] 何复英 廖颂明 陈妙风 

机构地区：[1]中山医科大学肿瘤研究所 [2]广州侨光制药厂

出　　处：《癌症》1989年第6期438-442,共5页Chinese Journal of Cancer

摘　　要：本文研究给小鼠腹腔注射含蛋氨酸的复方氨基酸液(AA_1)和低硫复方氨基酸液(AA_2)对小鼠肿瘤L_2生长影响的比较试验。4批实验表明,给AA_2液的小鼠平均瘤重各自为AA_1液组的61％,70％,71％和68％。小鼠自饮两种氨基酸液的结果亦相似。在Hela细胞体外微量培养,观察到添加蛋氨酸能使顺铂对Hela细胞的抑制率明显降低:在体内荷瘤小鼠3批实验也证明添加蛋氨酸能使阿霉素对小鼠L_2肿瘤的抑制率由59％51％和43％。降为19％28％和17％提示临床上应用顺铂和阿霉素治疗肿瘤病人时,不主张同时应用含蛋氨酸的复方氨基酸液。The influence of complex amino acid mixture containing methionine (AA 0 and without methionine (AA2) on the growth of reticulum cell sarcoma L2 in mice was studied. In 4 experiments, amino acid mixtures were administered intraperitoneally. The average tumor weight in mice of AA2 group was 61, 70,71 and 68% of the tumor weight in mice of AA1 group, respectively. In the experiments, where AA1 and AA2 were administered by drinking a ad Libidum, the results were similar to those in the intraperitoneal use groups.The influence of methionine on the antitumor activity of DDP or ADM were studied, in vitro and in vivo. In the microculture of HeLa cells, it was shown that methionine added into normal culture medium decreased markedly the inhibition rate of DDP on the growth of HeLa cells. It was demonstrated also that methionine could reduce the antitumor activity of ADM in mice. The inhibition rate of ADM on L2 tumor in mice was reduced from 59, 51 and 43% to 19, 28 and 17%, respectively. The differences were significant statistically.The results suggested that it is reasonable to avoid the use of complex amino acid mixture containing methionine in cancer patients, especially not in combination with DDP or ADM in order not to affect the therapeutic effect of the antitumor agents.

关 键 词：蛋氨酸 抗癌药 移植瘤 

分 类 号：R969.2[医药卫生—药理学]