Synthesis and Anti-inflammatory Action of (η-C_5H_5)_2Ti(Sal)_2 and (η-C_5H_5)_2Ti(Clo)_2  

作　　者：LI Xiu-juan ZENG Zheng-zhi 

机构地区：[1]College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China

出　　处：《Chemical Research in Chinese Universities》2006年第1期6-10,共5页高等学校化学研究（英文版）

基　　金：SupportedbytheNationalNaturalScienceFoundationofChina(No.20171019).

摘　　要：Two new complexes （Cp）2Ti （Sal）2 and（Cp）2Ti（Clo）2 （Cp=Cyclopentadienyl η^5-C5H5 ）, have been synthesized in anhydrous THF by the reaction of HSal（o-hydroxybenzoic acid, salicylate acid） or HClo[N-（ m-chloro-phenyl） anthranili acid, acidum clofenamicum] with （Cp）2TiCl2 and characterized by means of elemental analyses, IR, H NMR, ^13C NMR, UV and molar conductivity. In complex （Cp）2Ti（Sal）2 or（Cp）2Ti（Clo）2, the oxygen atom of the carboxyl group coordinates to Ti（Ⅳ） in a monodentate manner. The inhibitory action of the complexes on mouse ear tumefaction caused by croton oil and rat foot granulation growth caused by cotton balls is higher than that of the corresponding ligands HSal, HClo and [ （Cp）2TiCl2 ], whereas their toxicity is lower than those of the free ligands.Two new complexes （Cp）2Ti （Sal）2 and（Cp）2Ti（Clo）2 （Cp=Cyclopentadienyl η^5-C5H5 ）, have been synthesized in anhydrous THF by the reaction of HSal（o-hydroxybenzoic acid, salicylate acid） or HClo[N-（ m-chloro-phenyl） anthranili acid, acidum clofenamicum] with （Cp）2TiCl2 and characterized by means of elemental analyses, IR, H NMR, ^13C NMR, UV and molar conductivity. In complex （Cp）2Ti（Sal）2 or（Cp）2Ti（Clo）2, the oxygen atom of the carboxyl group coordinates to Ti（Ⅳ） in a monodentate manner. The inhibitory action of the complexes on mouse ear tumefaction caused by croton oil and rat foot granulation growth caused by cotton balls is higher than that of the corresponding ligands HSal, HClo and [ （Cp）2TiCl2 ], whereas their toxicity is lower than those of the free ligands.

关 键 词：Salicylate acid N-（m-Chlorophenyl） anthranilic acid Cyclopentadienyltitanium complexes Anti-in-flammatory 

分 类 号：O614.411[理学—无机化学] O641.4[理学—化学]