试论从中草药活性成分开发新型治疗阿尔茨海默病的酶抑制剂  

Developing Acetylcholinesterase Inhibitors for Curing Alzheimer's Disease from Active Constituents of Chinese Herbal Medicines

作　　者：金虹[1] 

机构地区：[1]西南科技大学生命科学与工程学院,四川绵阳621010

出　　处：《时珍国医国药》2006年第1期19-20,共2页Lishizhen Medicine and Materia Medica Research

基　　金：西南科技大学重大科技研究项目资助(No.ZK033129)

摘　　要：根据阿尔茨海默病发病机理的胆碱能假说及其最新的生理及病理学研究结果,对现有临床治疗阿尔茨海默病的乙酰胆碱酯酶抑制剂药物的特点及应用进行了概括和总结;根据中医药治疗老年痴呆及有关研究的现状,特别通过一些中药经体外酶抑制活性实验结果,论述从中草药活性成分开发新型治疗阿尔茨海默病抑制剂药物的趋势、方向及必要性和可行性。According to the suppositions on disease function of Alzheimer＇ s disease（AD） and it＇s new research results of physiology and pathology ,the characteristic and application of acetylcholinesterase inhibitors for treating AD in clinic were surveyed. In conjuction with present coditions of curing AD by traditional Chinese medica and basease on the test results of inhibit - acetylcholinesterasc out - body, the feasibility and necessity for develop new AD drugs of acctylcholinesterasc inhibitors from active constituents in Chinese herb medicines were recommended.

关 键 词：阿尔茨海默病 胆碱酯酶抑制刑 中草药 中医药 活性组分 

分 类 号：R965.1[医药卫生—药理学]