人参皂苷CK对四氯化碳致大鼠慢性肝损伤的影响  

Effect of Compound K on Chronic Hepatic Injury Induced by Carbon Tetrachloride (CCl_4) in Rats

作　　者：张雷明[1] 傅风华[1] 王天[1] 韩冰[1] 朱梅[1] 

机构地区：[1]烟台大学药学院,山东烟台264005

出　　处：《时珍国医国药》2006年第1期38-39,共2页Lishizhen Medicine and Materia Medica Research

摘　　要：目的研究人参皂苷CK对CC l4致慢性肝损伤的影响。方法用CC l4致大鼠慢性肝损伤模型,观察人参皂苷CK(0.3,1,3 mg/kg)对大鼠血清天冬氨酸转氨酶(aspartate transam inase,ALT)、丙氨酸转氨酶(alan ine transam inase,AST)、超氧化物歧化酶(superoxide d ismutase,SOD)、丙二醛(m alond ialdehyde,MDA)及透明质酸(hyaluron ic ac id,HA)、Ⅲ型前胶原(pre-collagenⅢ,PCⅢ)的影响,并对肝脏组织进行病理学观察。结果人参皂苷CK小剂量(0.3 mg/kg)能降低血清转氨酶ALT,AST水平,增加血清SOD的含量,降低MDA含量;CK中、高剂量无明显作用。CK各剂量组血清HA、PCⅢ和肝组织病理未见明显改变。结论CK低剂量对CC l4致慢性肝损伤具有一定的保护作用,其作用可能与抗氧化有关。Objective To observe the effect of Compound K on chronic hepatic injury induced by CCl4 in rats. Methods In male Wistar rats hepatic chronic injury was induced by the subcutaneous administration of CCl4 twice a week for six weeks. Then rats were given Compound K at dose of 0. 3, 1 or 3 mg/kg respectively for a further four weeks. At the end the biochemical parameters associated with hepatic injury were determined, and the histopathology of liver was observed. Results Compared with the model group, activities of alanine aminotransferase （ALT）, aspartate aminotransferase （AST） were significantly reduced by Compound K at dose of 0.3 mg/kg, accompanied with that the amount of superoxide dismutase （SOD） markedly increased and malondialde- hyde（MDA） reduced obviously, while no significant changes in the amount of hyaluronic acid （HA） and procollagen Ⅲ（PCⅢ） or histopathology were observed. Conclusion Compound K at low dose could protect liver from injury induced by CCl4, which may be associated with its antioxidation effect.

关 键 词：人参皂苷CK 肝损伤 谷丙转氨酶 谷草转氨酶 超氧化物歧化酶 

分 类 号：R285.5[医药卫生—中药学]